Week 1 of the 2025 college football season is in full swing on Saturday, and fans should use the latest DraftKings promo code, offering over $200 off on NFL Sunday Ticket as well as $300 in bonus bets. There will be games throughout the day, including No. 1 Texas vs. No. 3 Ohio State, No. 9 LSU vs. No. 4 Clemson, and California vs. Oregon State. DraftKings is the perfect outlet to get you prepared for this Week 1 slate of college football. Clemson is favored by 4 points in the latest Week 1 college football odds, while Oregon State is a 1.5-point favorite over California.

SportsLine’s computer model is taking the Ohio State vs. Texas Under 47.5 as one of its top college football predictions this week. Before locking in your Week 1 college football picks on your favorite betting sites like DraftKings, you’ll also want to be sure to check out the top college football betting picks from SportsLine’s proven computer model. Claim the latest DraftKings bonus code here, where new users get $300 in bonus bets, in addition to more than $200 off NFL Sunday Ticket: 

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and was a profitable 27-16 combined on money-line and over/under college football picks in 2024. Anybody following its college football betting picks on betting sites could have seen strong returns.

Best Week 1 college football picks: 

Under 47.5 total points: Texas vs. Ohio StateOver 57.5 total points: LSU vs. ClemsonCalifornia moneyline (+100) vs. Oregon State 

Combining the model’s three picks into a Week 1 college football parlay at DraftKings would result in a payout of +617 (risk $100 to win $617). Bet it at DraftKings here:

Texas vs. Ohio State: Under 47.5 total points

A battle between top-three teams goes down when Texas and Ohio State clash. This is a rematch of the Cotton Bowl last season, where Ohio State came away with a 28-14 win. Arch Manning is the starter for the Longhorns, with Julian Sayin taking the reins for Ohio State. They have tall tasks, considering these schools have some of the most elite defenses in the country. The Buckeyes led the nation in yards per play (4.19), total defense (254.6), and scoring defense (12.8) last season. As for Texas, it was third in the FBS in scoring defense (15.3) and total defense (283.4). SportsLine’s model has the Under cashing in 57% of simulations. 

LSU vs. Clemson: Over 57.5 total points

This contest features two exciting offenses. Last season, Clemson was 11th in the nation in total offense (451.9 yards per game) and 18th in scoring offense (34.7 points per game). On the other sideline, LSU had the 25th-ranked total offense (431.5 ypg) along with 30.5 points per contest. Cade Klubnik leads the charge for Clemson after racking up 3,639 passing yards, 463 rushing yards, and 43 total touchdowns last season. Garrett Nussmeier also returns, as he tossed 4,052 passing yards and 29 touchdowns in 2024 for LSU. SportsLine’s model predicts these teams to score 64 points in this matchup. 

California moneyline (+100) vs. Oregon State

California spent its first season in the ACC last year and finished with a 6-7 record. Justin Wilcox enters his ninth season as the coach of the Golden Bears. The Beavers logged a 5-7 record in 2024 and failed to qualify for a bowl game for the first time in three years. In last season’s contest between these schools, California came away with a commanding 44-7 win. The Beavers also went 2-5 ATS as the favorite last campaign. The model is projecting the Golden Bears to win in 52% of simulations. 

Want more Week 1 college football picks?

You’ve seen the model’s Week 1 college football best bets. Now, get against the spread, total and money-line picks for every Week 1 CFB game here, all from the model that’s simulated every game 10,000 times. 

Also at SportsLine:

You can also see Week 1 college football picks from legendary college football handicapper Bruce Marshall. Visit SportsLine to see his best bets. SportsLine’s Emory Hunt, who is 45-32 in his last 77 college football picks, has locked in his best bet for Oregon State vs. California right here.