The Cardinals are favored by nearly a touchdown against the Saints at the start of Week 1.
The Arizona Cardinals will open the 2025 season this week. Following an 8-9 season in 2024 and big moves in the offseason to improve the defense, they open the season on the road against the New Orleans Saints.
The Cardinals and Saints kick off Sunday from Caesars Superdome in New Orleans at 1 p.m. ET (10 a.m. Arizona time).
Let’s have a look at the betting odds and lines for the game as we start the week.
Cardinals at Saints betting odds and lines for Week 1
Odds come from BetMGM Sportsbook as of Monday night.
Moneyline
Cardinals -300 (bet $300 to win $100)Saints +240 (bet $100 to win $240)
The Cardinals are heavily favored on the road. The odds imply the Cardinals are about 46% more likely to win than the Saints.
Against the spread (ATS)
Cardinals -6.5 (-110)Saints +6.5 (-110)
When odds first came out in May, the Cardinals were 3.5-point favorites. The line shifted to 5.5 points and, more recently, it moved to nearly a touchdown.
A $110 ATS bet on the Cardinals wins $100 if they beat the Saints by at least seven points.
A $110 ATS bet on the Saints cashes in $100 if they win, tie or lose by no more than six points.
Total (Over/Under)
Over 43 (-110)Under 43 (-110)
If the Cardinals and Saints combine for at least 44 points, a $110 bet on the Over wins $100.
If they combine for 42 or fewer, a $110 bet on the Under wins $100.
No matter the bet, if they finish with a total of 43, the bets are canceled and everyone is refunded.
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