We’re nearly there. The start of the 2025 NFL season.
The Buffalo Bills are hoping to finally make it over the Super Bowl hump and crack the championship game. Can this group led by quarterback Josh Allen finally make it all the way?
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Let’s have a prediction now.
Here is Bills Wire’s game-by-game predictions for the 2025 season:
Jan 11, 2025; Baltimore, Maryland, USA; A view of Baltimore Ravens players’ helmets on a heated bench against the Pittsburgh Steelers in an AFC wild card game at M&T Bank Stadium. Mandatory Credit: Geoff Burke-Imagn Images
The Ravens are a good team and it feels like they could be due for a win against the Bills in a big AFC clash.
Prediction: Loss (0-1).
Week 2: at New York Jets
Aug 17, 2024; Charlotte, North Carolina, USA; New York Jets helmets during the second half against the Carolina Panthers at Bank of America Stadium. Mandatory Credit: Jim Dedmon-USA TODAY Sports
It’s a new regime leading the Jets and this game will be early days for them.
Prediction: Win (1-1).
Aug 3, 2022; Miami Gardens, Florida, US; A general view of a Miami Dolphins helmet on the field during training camp at Baptist Health Training Complex. Mandatory Credit: Jasen Vinlove-USA TODAY Sports
After a season-opening loss, the Bills will be motivated to stack wins against the Dolphins–who are a team that quarterback Josh Allen thrives against.
Prediction: Win (2-1).
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Jun 10, 2025; New Orleans, LA, USA; Detailed view of the Saints helmet during minicamp at Ochsner Sports Performance Center. Mandatory Credit: Stephen Lew-Imagn Images
The Saints have so many question marks… these are games the Bills should win.
Prediction: Win (3-1).
Week 5: vs. New England Patriots (SNF)
Jan 13, 2025; Foxborough, MA, USA; A pair of New England Patriots helmets sit in front of the podium before a press conference at Gillette Stadium. Mandatory Credit: Eric Canha-Imagn Images
While the Patriots are looking for a positive season, it still looks like the Bills are much better on paper and should take this one… and there will be motivation as Stefon Diggs returns to Buffalo.
Prediction: Win (4-1).
Week 6: at Atlanta Falcons (MNF)
Nov 10, 2024; New Orleans, Louisiana, USA; Detailed view of the Atlanta Falcons helmet against the New Orleans Saints during the second half at Caesars Superdome. Mandatory Credit: Stephen Lew-Imagn Images
Heading into the bye is motivation for the Bills and the Falcons are a young team.
Prediction: Win: (5-1).
Week 7: Bye
Record: (5-1).
Week 8: at Carolina Panthers
Nov 10, 2019; Green Bay, WI, USA; A Carolina Panthers helmet sits on the field during warmups prior to the game against the Green Bay Packers at Lambeau Field. Mandatory Credit: Jeff Hanisch-USA TODAY Sports
It’s hard to bet against Buffalo head coach Sean McDermott after the bye. He’s 8-0 in such games.
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Prediction: Win (6-1).
Week 9: vs. Kansas City Chiefs
Feb 9, 2025; New Orleans, LA, USA; A detail view of Kansas City Chiefs helmets before Super Bowl LIX between the Philadelphia Eagles and the Kansas City Chiefs at Caesars Superdome. Mandatory Credit: Geoff Burke-Imagn Images
It should be another classic between these two…
Prediction: Win (7-1).
Week 10: at Miami Dolphins
Aug 3, 2022; Miami Gardens, Florida, US; A general view of a Miami Dolphins helmet on the field during training camp at Baptist Health Training Complex. Mandatory Credit: Jasen Vinlove-USA TODAY Sports
While the Bills do dominate the AFC East, it’s hard to sweep a division every season… and the Dolphins have to eventually be due against the Bills, right?
Prediction: Loss (7-2).
Week 11: vs. Tampa Bay Buccaneers
Oct 13, 2024; New Orleans, Louisiana, USA; Detailed view of the Tampa Bay Buccaneers helmet against the New Orleans Saints during the first half at Caesars Superdome. Mandatory Credit: Stephen Lew-Imagn Images
A loss in Week 10 will be bad news for the Bucs.
Prediction: Win (8-2).
Week 12: at Houston Texans (TNF)
Aug 9, 2024; Pittsburgh, Pennsylvania, USA; A Houston Texans helmet sits on the sidelines during the 4th quarter against the Pittsburgh Steelers at Acrisure Stadium. Mandatory Credit: Barry Reeger-USA TODAY Sports
While there is no more Stefon Diggs in Houston, the Bills will remember how poorly they played there in 2024.
Prediction: Win: (9-2).
Week 13: at Pittsburgh Steelers
Dec 15, 2024; Philadelphia, Pennsylvania, USA; Pittsburgh Steelers helmet on the sidelines against the Philadelphia Eagles at Lincoln Financial Field. Mandatory Credit: Eric Hartline-Imagn Images
The Steelers do play the Bills well on occasion (or get blown out), but there are too many question marks for them currently.
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Prediction: (10-2).
Dec 1, 2024; Cincinnati, Ohio, USA; A general view of the helmet of Cincinnati Bengals long snapper Cal Adomitis (48) during warmups before the game against the Pittsburgh Steelers at Paycor Stadium. Mandatory Credit: Katie Stratman-Imagn Images
The Bengals are hoping for a massive bounce-back season and this would be a huge game for them… assuming they will improve.
Prediction: Loss (10-3).
Week 15: at New England Patriots
Jan 13, 2025; Foxborough, MA, USA; A pair of New England Patriots helmets sit in front of the podium before a press conference at Gillette Stadium. Mandatory Credit: Eric Canha-Imagn Images
As the postseason approaches, the Bills will still be too much for the Pats.
Prediction: Win (11-3).
Week 16: at Cleveland Browns
Nov 17, 2024; New Orleans, Louisiana, USA; Detailed view of the Cleveland Browns helmets on a time out against the New Orleans Saints during the first half at Caesars Superdome. Mandatory Credit: Stephen Lew-Imagn Images
The Browns are just all over the place despite having a decent defense.
Prediction: Win (12-3).
Week 17: vs. Philadelphia Eagles
Feb 9, 2025; New Orleans, LA, USA; A Philadelphia Eagles player’s helmet rests on the field after Super Bowl LIX against the Kansas City Chiefs at Caesars Superdome. Mandatory Credit: Geoff Burke-Imagn Images
Super Bowl preview? A fun one could unfold here.
Prediction: Win (13-3).
Week 18: vs. New York Jets
Aug 17, 2024; Charlotte, North Carolina, USA; New York Jets helmets during the second half against the Carolina Panthers at Bank of America Stadium. Mandatory Credit: Jim Dedmon-USA TODAY Sports
There could be something on the line here… or maybe not. Either way, there’s no way the final game at the current Highmark Stadium should be a loss.
Prediction: Win (14-3).
This article originally appeared on Bills Wire: 2025 NFL schedule: Game-by-game predictions for the Bills