The Tennessee Titans are set to open the 2025 regular season on the road against the Denver Broncos at Mile High Stadium in what should make for an interesting matchup to kick off the Cam Ward era in Tennessee. 

There is no doubt that the Titans will have their hands full during this game. Not only do the Broncos boast one of the best defenses in the league, but they also play in one of the more hostile environments for opposing teams. While the Titans appear to be much improved from their disastrous 2024 campaign, they are a relatively young team and will be starting a rookie quarterback.

The Broncos surprised many pundits, going 10-7 last season behind quarterback Bo Nix, and grabbed the final spot in the playoffs before falling to the Buffalo Bills. Now, after adding some more talent, they are poised to go even further in Nix’s second season in the league. 

With all signs pointing toward the Broncos, it comes as no surprise that the team at BetMGM has them at 8.5-point underdogs to close the week with the over/under set at 42.5 total points. The money for the Titans is +350, and for the Broncos is -450.

This should be an interesting battle, a fun game to watch, and most importantly, a chance for Ward to show why the Titans made him their first-overall selection in the 2025 NFL draft.Â