Tight end Isaiah Likely and fullback Patrick Ricard are both out versus the Bills this Sunday, the team announced on Friday.
Likely has been out of practice after undergoing foot surgery at the start of training camp.
Ricard hasn’t practiced all week with a foot injury.
Cornerback Jaire Alexander and offensive guard Daniel Faalele were both limited at Wednesday’s practice, but they are not designated with injuries ahead of week one vs. Buffalo.