Panthers at Jaguars odds, picks and predictions

The Carolina Panthers and the Jacksonville Jaguars play Sunday at EverBank Stadium in Jacksonville. Kickoff is scheduled for 1 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Panthers vs. Jaguars odds and make our expert NFL picks and predictions for the best bets.

The Panthers head into this game looking to improve upon last season’s 5-12 mark. Against AFC opponents, Carolina was 1-4 straight up (SU) and 2-3 against the spread (ATS) in 5 games.

Carolina QB Bryce Young showed slight improvement in 2024, completing 60.9% of his passes for 2,403 yards with 15 TDs and 9 INTs, though protection remained a key issue. He was sacked 62 times in 16 games during his rookie campaign in 2023, but that number dropped to 29 sacks across 14 games last season.

The Panthers went out and selected WR Tetairoa McMillan from Arizona. He posted 174 receptions for 2,721 yards and 18 TDs across his past 2 seasons for the Wildcats. He will pair with WR Xavier Legette, the team’s first-round pick in 2024, as the starting receiver duo.

Jacksonville finished 4-13 SU in 2024, while going 0-5 SU and 3-2 ATS in 5 matchups against the NFC. The Over cashed in 4 of those 5 outings.

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Panthers at Jaguars odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 10:29 p.m. ET.

Moneyline (ML): Panthers +155 (bet $100 to win $155) | Jaguars -190 (bet $190 to win $100)Against the spread: Panthers +3.5 (-110) | Jaguars -3.5 (-110)Over/Under (O/U): 46.5 (O: -118 | U: -110)

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Panthers at Jaguars key injuries

Panthers

OT Ikem Ekwonu (illness) doubtfulDB Damarri Mathis (knee) out

Jaguars

CB Montaric Brown (ankle) outOL Wyatt Milum (knee) outOL Cole Van Lanen (shoulder) questionablePanthers at Jaguars picks and predictionsPrediction

Jaguars 25, Panthers 16

The Jaguars (-190) will cost you nearly 2 times your potential return, and that’s way too much risk for not enough reward. My personal limit for a standalone wager on the moneyline is -180.

Including Jacksonville in a multi-leg parlay — or using a promo or boost — would be perfectly acceptable, however.

AVOID betting this straight up, though, and look to the spread instead.

The JAGUARS -3.5 (-110) are worth playing in this home matchup despite their lack of success against the NFC in 2024.

Jacksonville is 5-3 ATS in its past 8 season openers, while Carolina has gone 0-2 SU/ATS in its last 2, losing by an average of 25.5 points per game, and is 0-3 SU/ATS in its past 3 Week 1 games.

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UNDER 46.5 (-110) is the play in this AFC vs. NFC battle in Duval.

The Jaguars’ strength this season may lie in their running game, with RBs Tank Bigsby and Travis Etienne Jr. both proving highly effective. Rookie RB Bhayshul Tuten is also in the mix, making a name for himself in training camp and the preseason. However, strong run teams run the clock.

While Carolina added T-Mac to the receiving ranks, RB Chuba Hubbard is still the best player on offense, and the pass game is missing WR Jalen Coker, as he begins the season on the Reserve/Injured list. The Panthers could be a bit conservative to start.

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Panthers at Jaguars odds, picks and predictions

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