The NFC North spotlight shifts to Detroit on Sunday, where the Lions host the Chicago Bears in a divisional clash at Ford Field. Both teams enter Week 2 with plenty to prove: the Bears looking to show that rookie quarterback Caleb Williams can deliver in tough road environments, and the Lions eager to build on their standing as one of the NFC’s most consistent playoff contenders.

Oddsmakers lean toward Detroit, listing the Lions as 5.5-point favorites with a moneyline of -250, while the Bears sit at +220 to pull the upset. The total is set at 47.5, reflecting expectations for a competitive game with offensive fireworks on both sides. According to Dimers.com’s data-driven model, the Lions hold a 71% chance of winning, though Chicago has enough playmakers to keep things close.

Key matchups to watch include Williams targeting DJ Moore against a Lions secondary that struggled at times last season, and Detroit’s backfield duo of Jahmyr Gibbs and David Montgomery testing Chicago’s defensive front. With early divisional positioning on the line, Sunday’s meeting could serve as a tone-setter for the rest of the NFC North race.

Bears vs. Lions betting preview

Explore the interactive widget below to see the latest spread, total, and moneyline betting odds and probabilities for the Bears-Lions matchup at Ford Field.

This prediction and best bet for Sunday’s NFL matchup between the Bears and Lions is from Dimers.com, a leader in sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

Key information on the Bears vs. Lions matchup, including where the game is and what time it kicks off.

Teams: Chicago Bears vs. Detroit LionsDate: Sunday, September 14, 2025Kickoff: 1 p.m. ETLocation: Ford FieldNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

The latest and best odds for the NFL clash between the Bears and Lions.

Spread: Bears +5.5 (-108), Lions -5.5 (-110)Moneyline: Bears +220, Lions -250Total: Over/Under 47.5 (-104/-118)

The odds and lines presented in this article are the best available from selected sports betting sites at the time of publication and are subject to change.

Promos

Note: Lions fans in Michigan can use the BetMGM bonus code “CUSE150″ to unlock exclusive offers, while the Bet365 bonus code “SYRACUSE” is perfect for Bears fans in Illinois.

Expert prediction: Bears vs. Lions

Leveraging cutting-edge data analysis and advanced algorithms, the experts at Dimers have performed 10,000 simulations of Sunday’s Bears vs. Lions matchup.

According to Dimers’ independent predictive analytics model, the Lions are more likely to defeat the Bears at Ford Field. This prediction is based on the model giving the Lions a 71% chance of winning the game.

Furthermore, Dimers predicts that the bookies have gotten it right and the Bears and Lions each have a 50% chance of covering the spread, while the over/under total of 47.5 points is also considered an equal 50-50 chance of hitting.

These predictions and probabilities are correct at the time of publication but are subject to potential changes.

Bears vs. Lions best bet

Our top pick for the Bears vs. Lions Week 2 NFL game is to bet on the Lions moneyline (-250).

This betting advice is based on world-class simulations and valuable wagering intelligence, designed to bring you the best possible plays.

Score prediction for Bears vs. Lions

Dimers’ projected final score for the Chicago vs. Detroit game on Sunday has the Lions winning 26-20.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL player props: Sunday

NFL player prop bets are a popular way to wager on Sunday’s game without necessarily betting on its outcome.

This article features the most likely first and anytime touchdown scorers for the Bears and Lions, as well as projected player stats.

Chicago BearsFirst touchdown scorer predictionsD’Andre Swift: 8.2% probabilityDJ Moore: 6.8% probabilityRome Odunze: 5.7% probabilityAnytime touchdown predictionsD’Andre Swift: 35.4% probabilityDJ Moore: 30.7% probabilityRome Odunze: 26.4% probabilityProjected box score leadersQB passing yards: Caleb Williams, 222 yardsReceiving yards: DJ Moore, 56 yardsRushing yards: D’Andre Swift, 57 yardsDetroit LionsFirst touchdown scorer predictionsJahmyr Gibbs: 13.6% probabilityDavid Montgomery: 13.1% probabilityAmon-Ra St. Brown: 8.1% probabilityAnytime touchdown predictionsJahmyr Gibbs: 58.0% probabilityDavid Montgomery: 56.5% probabilityAmon-Ra St. Brown: 40.1% probabilityProjected box score leadersQB passing yards: Jared Goff, 253 yardsReceiving yards: Amon-Ra St. Brown, 74 yardsRushing yards: Jahmyr Gibbs, 80 yardsNFL Week 2: Bears vs. Lions

Get ready for Sunday’s game between the Bears and Lions in Week 2 of the NFL season at Ford Field, which is scheduled to start at 1 p.m. ET. We emphasize that all of the NFL predictions and NFL best bets in this preview are derived from 10,000 data-driven simulations of the Bears vs. Lions matchup, and they are correct at the time of publishing to help you make better decisions when placing bets at online sportsbooks.

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