The Arizona Cardinals (1-0) face the Carolina Panthers (0-1) on Sunday, September 14, 2025 at State Farm Stadium. The Cardinals are listed as favorites in this one, with the spread sitting at 6.5 points. The over/under for the outing is 44.5 points.
The Cardinals beat the New Orleans Saints, 20-13, in their most recent contest.
In that matchup versus the Saints, Cards quarterback Kyler Murray completed 21 of 29 passes for 163 yards, with two touchdowns and no interceptions.
The Panthers’ last contest was against the Jacksonville Jaguars, and they lost by a score of 26-10.
Cardinals vs Panthers betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Sunday at 12:59 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Arizona (-6.5)Moneyline: Arizona (-308), Carolina (+247)Total: 44.5 pointsCardinals 2024 betting insightsArizona was 6-3 overall, and 6-3 against the spread, at home last season.The Cardinals had 11 wins in 17 games against the spread last year.Arizona went over the total in five of nine home games last year.In 17 Cardinals games last season, eight hit the over.Cardinals players to watch (2024 stats)Murray: 3,851 PASS YDS / 226.5 YPG / 68.8% / 21 TD / 11 INT / 78 CAR / 572 RUSH YDS / 5 TDJames Conner: 236 CAR / 1,094 YDS / 68.4 YPG / 8 TD / 47 REC / 414 YDS / 25.9 YPG / 1 TDTrey McBride: 111 REC / 1,146 YDS / 71.6 YPG / 2 TDMarvin Harrison Jr.: 62 REC / 885 YDS / 52.1 YPG / 8 TDMichael Wilson: 47 REC / 548 YDS / 34.3 YPG / 4 TDCardinals vs Panthers game infoDate: Sunday, September 14, 2025Time: 4:05 p.m. ETCity: Glendale, ArizonaVenue: State Farm StadiumTV channel: CBSLive stream: Watch on Fubo (Regional restrictions may apply)Live stream: Watch on Paramount+ (Regional restrictions may apply)
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