The Philadelphia Eagles return home in Week 3 looking to establish momentum after a shaky start to their 2025 campaign. Jalen Hurts and company enter Sunday’s matchup against the Los Angeles Rams as 4.5-point favorites, and the early numbers suggest they’ll have the edge at Lincoln Financial Field. Still, with questions lingering about Philadelphia’s ability to finish drives and protect leads, this game could be a measuring stick for where the Eagles stand in a crowded NFC race.

For the Rams, this trip to Philadelphia represents both a test and an opportunity. Matthew Stafford remains at the helm of Sean McVay’s offense, and his chemistry with young playmakers has kept Los Angeles competitive early in the season. The Rams are underdogs, but the spread suggests oddsmakers expect them to hang around. With a 54% projected chance to cover the 4.5 points, according to Dimers’ model, Los Angeles has the kind of profile that could make life difficult for the Eagles’ secondary.

The stakes are clear: Philadelphia has a 65% chance of winning outright, but Los Angeles brings enough balance on both sides of the ball to make this far from a guaranteed result. With the over/under sitting at 46.5, the numbers point toward a fairly tight contest, one that may be decided by turnovers or late-game execution. For both franchises, Week 3 is a chance to either settle into rhythm—or slip further into uncertainty as the 2025 NFL season begins to take shape.

Rams vs. Eagles betting preview

Utilize the interactive widget below to discover the latest spread, over/under, and moneyline betting odds and probabilities for the Rams-Eagles matchup at Lincoln Financial Field.

This prediction and best bet for Sunday’s NFL matchup between the Rams and Eagles is from Dimers.com, a trusted source for sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

The key information you need before the Rams vs. Eagles NFL game.

Teams: Los Angeles Rams vs. Philadelphia EaglesDate: Sunday, September 21, 2025Kickoff: 1 p.m. ETLocation: Lincoln Financial FieldNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

Odds for the key markets in the Rams-Eagles NFL matchup.

Spread: Rams +4.5 (-105), Eagles -4.5 (-115)Moneyline: Rams +180, Eagles -218Total: Over/Under 46.5 (-110/-110)

The odds and lines featured here are the best available from selected sports betting sites at the time of publication and are subject to change.

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Expert prediction: Rams vs. Eagles

Utilizing advanced data analysis and machine learning, the experts at Dimers have performed 10,000 simulations of Sunday’s Rams vs. Eagles game.

According to Dimers’ highly acclaimed predictive analytics model, the Eagles are more likely to defeat the Rams at Lincoln Financial Field. This prediction is based on the model giving the Eagles a 65% chance of winning the game.

Furthermore, Dimers predicts that the Rams (+4.5) have a 54% chance of covering the spread, while the over/under total of 46.5 points has a 53% chance of staying under.

As always, these predictions and probabilities are correct at the time of publication but are subject to change.

Rams vs. Eagles best bet

Our top pick for the Rams vs. Eagles Week 3 NFL matchup is to bet on the Rams +4.5 (-105).

This expert betting advice is formulated through detailed modeling and valuable wagering intelligence, designed to help you make more informed investments.

Score prediction for Rams vs. Eagles

Dimers’ predicted final score for the LA Rams vs. Philadelphia game on Sunday has the Eagles winning 24-20.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL Week 3: Rams vs. Eagles

Get ready for Sunday’s action between the Rams and Eagles in Week 3 of the National Football League season at Lincoln Financial Field, which is scheduled to start at 1 p.m. ET. We emphasize that all of the NFL best bets and NFL predictions in this article are derived from 10,000 data-driven simulations of the Rams vs. Eagles matchup, and they are accurate at the time of publishing. They aim to assist you make more informed choices when placing bets at online sportsbooks.

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