The Buffalo Bills (2-0) are 12.5-point favorites when they host the Miami Dolphins (0-2) in an AFC East matchup on Thursday, September 18, 2025 at Highmark Stadium.
Bills vs. Dolphins game info
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Bills vs. Dolphins odds & betting linesSpread favorite: Buffalo (-12.5)Moneyline: Buffalo (-820), Miami (+558)Total: 49.5 points
NFL odds courtesy of BetMGM Sportsbook. Odds updated Monday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Bills vs. Dolphins recent matchupsIn the last five meetings between the Bills and Dolphins, Buffalo has gone 5-0.The Bills have a 3-2 record against the spread in those games versus the Dolphins, and the two squads eclipsed the point total on three occasions.Buffalo outscored Miami 164-102 in those five head-to-head matchups.Bills vs. Dolphins betting insightsBuffalo, through two games with a spread so far this season, has gone 2-0-0 against the spread. The Bills won the only game they played as the moneyline favorite this season. Miami has not won a game against the spread this season (0-2-0). This will be the second game this year the Dolphins are an underdog on the moneyline. They lost the first.Bills scoring insightsThe Bills rank 22nd in the NFL with 25.0 points per game allowed on defense over the last three contests, but they’ve really been thriving on offense, as they rank second-best with 35.5 points per game during that time frame.Dolphins scoring insightsThe Dolphins are scoring 17.5 points per game in their past three games (26th in league), and conceding 33.0 per game (second-worst).Bills injury reportBills:
Matt Milano: Did Not Participate In Practice (Pectoral),
Jordan Hancock: Full Participation in Practice (Shoulder),
Shaq Thompson: Limited Participation in Practice (Hamstring),
Cameron Lewis: Limited Participation in Practice (Shoulder),
Taron Johnson: Limited Participation in Practice (Quad),
Ed Oliver: Did Not Participate In Practice (Ankle)Dolphins injury reportDolphins:
Storm Duck: Did Not Participate In Practice (Ankle),
Jaylen Wright: Limited Participation in Practice (Knee),
Malik Washington: Limited Participation in Practice (Thumb),
Darren Waller: Limited Participation in Practice (Hip),
Chop Robinson: Limited Participation in Practice (Knee),
Benito Jones: Limited Participation in Practice (Oblique),
Aaron Brewer: Limited Participation in Practice (Hip),
Ethan Bonner: Limited Participation in Practice (Hamstring),
Ifeatu Melifonwu: Did Not Participate In Practice (Calf)
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