The Indianapolis Colts (2-0) visit the Tennessee Titans (0-2) this afternoon in a Week 3 AFC South showdown at Nissan Stadium in Nashville.

Indianapolis enters unbeaten, riding momentum behind quarterback Daniel Jones, rookie tight end Tyler Warren, and a defense that’s regaining health.

Jones has been sharp through two weeks, far surpassing expectations. The former New York Giants QB has completed 45 of 63 passes (71.4%) for 588 yards, 2 touchdowns, and no interceptions, good for a 111.1 passer rating. His ability to stay efficient under pressure has steadied a Colts offense that looks far more balanced than last season.

The Titans, meanwhile, are still searching for their first win under new leadership. Rookie QB Cam Ward has shown flashes but is enduring growing pains, completing just 31 of 61 passes (50.8%) for 287 yards and 1 touchdown through two games. Tennessee’s offensive line issues have left him vulnerable, limiting his ability to stretch the field and keeping the offense stuck in low gear.

Adding to the divisional stakes: last year’s AFC South champion, the Houston Texans (0-2), have stumbled to a poor start in 2025. That gives the Colts a real opportunity to seize early control of the division with a 3-0 record.

4 Things to Watch

Colts’ key players returning

Cornerback Charvarius Ward has cleared concussion protocol, and rookie tight end Tyler Warren is fully healthy after a toe injury. Both give the Colts added strength on defense and offense.

Titans lose T’Vondre Sweat to IR

Defensive tackle T’Vondre Sweat was placed on injured reserve with an ankle injury, leaving Tennessee thin in the trenches against Indy’s rushing attack.

Jonathan Taylor vs. Titans’ run defense

With Sweat out, the Titans’ ability to contain Taylor will be critical. If Indianapolis controls the run game, it could open passing lanes for Jones.

Urgency factor

At 0-2, Tennessee faces the risk of falling three games behind early. The Colts want a 3-0 start to strengthen their divisional position, giving both teams plenty of urgency.

Predictions

The Colts have the edge thanks to roster health and momentum. Their defensive depth returning at key spots should help keep Tennessee’s passing attack in check. Meanwhile, Jonathan Taylor has a favorable matchup against a weakened Titans front. If Tennessee can’t establish a run game or protect their QB consistently, they’ll struggle to keep pace.

Projected Final Score: Colts 27, Titans 17

Injury Report

Indianapolis Colts

CB Charvarius Ward — Available

TE Tyler Warren — Available

Tennessee Titans

OT JC Latham — Out

DT T’Vondre Sweat — Out

RB Kalel Mullings — Questionable

WR Bryce Oliver — Questionable

CB Jarvis Brownlee Jr. — Questionable

CB L’Jarius Sneed — Questionable

G Kevin Zeitler — Questionable

How to Watch Colts vs. Titans

Kickoff for this afternoon’s game between the Indianapolis Colts and the Tennessee Titans is set for 1:00 PM Eastern / 12:00 PM Central at Nissan Stadium, Nashville, TN.

The game airs live on CBS across Indiana and Tennessee. It also streams live on the CBS and CBS Sports apps and websites.

Fans outside those regions can watch on YouTube’s NFL Sunday Ticket, starting at $34.50 per month.

If you’re a cordcutter without a livestreaming subscription, you can watch today’s game for free by signing up for a trial with FuboTV, YouTube TV, Hulu + Live TV, or DirecTV Stream.

YouTube TV also provides a 20-minute free preview without requiring registration.

Indianapolis Colts vs. Tennessee Titans

Date: Sunday, September 21, 2025

Time: 1:00 PM Eastern / 12:00 PM Central

Venue: Nissan Stadium, Nashville, TN

TV: CBS

Streaming: CBS and CBS Sports apps and websites, Paramount+, NFL+, YouTube TV (NFL Sunday Ticket)