NFL Week 3 overreactions
USA Today’s Lorenzo Reyes breaks down the biggest NFL storylines from Week 3.
Sports Seriously
The Jacksonville Jaguars and San Francisco 49ers play on Sunday, Sept. 28, at the 49ers’ Levi’s Stadium in a game on the NFL Week 4 schedule.
Which team will win the NFL Week 4 game?
Check out these NFL Week 4 picks and NFL Week 4 predictions for the game, which can be seen at 1:05 p.m. MST on FOX (stream with FUBO).
The 49ers are a 3-point favorite over the Jaguars in NFL Week 4 odds for the game, courtesy of BetMGM Sportsbook.
San Francisco is -185 on the moneyline, while Jacksonville is +150. The over/under (point total) is set at 47 points.
NFL Week 4 picks: Seahawks at Cardinals | Vikings vs Steelers | Commanders at Falcons | Saints at Bills | Browns at Lions | Titans at Texans | Panthers at Patriots | Chargers at Giants | Eagles at Buccaneers | Colts at Rams | Jaguars at 49ers | Ravens at Chiefs | Bears at Raiders | Packers at Cowboys | Jets at Dolphins | Bengals at Broncos | The Republic’s score predictions
Watch Jaguars at 49ers live on FUBO (free trial)
Jeremy Cluff writes: “The 49ers have outscored their opponents by just 10 points in their 3-0 start. We expect another close game in this one, with a close San Francisco win. This team just finds ways to win, even amid a lot of injuries. Expect some huge Christian McCaffrey plays to seal the victory.”
Bookies.com: Bet the 49ers to cover vs Jaguars
Bill Speros writes: “The Mac Jones Revenge Tour gets a crack at one of his former teams when the 49ers play host to Jacksonville. Mac is 2-0 as Brock Purdy’s replacement, leading a come-from-behind drive to win it Sunday for the 3-0 but battered 49ers. The Jaguars are 2-1 thanks to 9 turnovers on defense. They beat Houston at home Sunday but won’t have the Florida heat to help them this week. Hold on tight, CMC.”
The site’s formula predicts that the Jaguars will win the NFL Week 4 game against the 49ers.
ESPN: 49ers have a 49.9% chance to beat Jaguars on Sunday
The site gives the Jaguars a 49.7% shot at winning the NFL Week 4 game, with the remaining percentage accounting for a tie.
Dimers: 49ers 26, Jaguars 22
It writes: “After extensive simulations, our model gives the Jaguars a win probability of 33%, while the 49ers have a win probability of 67%.”
Sportsnaut: 49ers 23, Jaguars 17
Matt Johnson writes: “This might be one of the most underrated games on the NFL schedule this weekend. Much of the Jacksonville Jaguars‘ success this season is thanks to a defense that leads the league in takeaways (nine) and the new-look ground game drawn up by Liam Coen that is averaging 5.1 yards per carry and 141.7 rushing yards per game. Last season, that recipe would’ve led to an upset over the San Francisco 49ers. In 2025, against a defense allowing just 3.7 ypc, that will prove harder. If the Jaguars knock out the 3-0 49ers, it will once again be thanks to this defense’s ability to create interceptions.”
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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