At Highmark Stadium on Sunday, James Cook and the Buffalo Bills (3-0) meet Juwan Johnson and the New Orleans Saints (0-3) in a battle featuring two of the biggest stars in the league offensively, starting at 1 p.m. ET.
The Bills enter the matchup after winning 31-21 over the Miami Dolphins in their last game on Sept. 18. The Saints’ most recent outing finished in a 44-13 loss to the Seattle Seahawks. Josh Allen had 213 yards on 22-of-28 passing (78.6%) for the Bills in that matchup against the Dolphins, with three touchdowns and no interceptions. He also added four carries for 25 yards. Cook took 19 carries for 108 yards (5.7 yards per carry) and one touchdown, while adding three receptions for 10 yards in the passing game. Dalton Kincaid had 66 yards on five catches (13.2 per reception) with one touchdown in that game. Spencer Rattler threw for 218 yards for the Saints against the Seahawks, going 28-for-39 (71.8%) with one touchdown and one interception. Alvin Kamara carried the ball 18 times for 42 yards. He caught one pass for 14 yards. Chris Olave collected 10 catches for 57 yards (on 14 targets).
Below in this article, we’ll give all the details you need to know about how to view this game on Fubo.
Watch Buffalo Bills vs. New Orleans Saints on Fubo! (Regional restrictions may apply)
Bills vs. Saints game infoGame day: Sunday, September 28, 2025Game time: 1 p.m. ETLocation: Orchard Park, New YorkStadium: Highmark StadiumTV channel: CBS (KLFY-Lafayette, LA)Live stream: Fubo (Watch Now!)Live stream: Paramount+ (Watch Now!)
Watch Buffalo Bills vs. New Orleans Saints on Fubo! (Regional restrictions may apply)
Bills vs. Saints betting info
NFL odds courtesy of BetMGM Sportsbook. Odds updated Friday at 3:05 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Bills (-15.5)Moneyline: Bills (-2000), Saints (+1000)Total: 48 points
Watch Buffalo Bills vs. New Orleans Saints on Fubo! (Regional restrictions may apply)