The New Orleans Saints (0-3) take a three-game losing streak into their contest with the New Orleans Saints (3-0) on Sunday, September 28, 2025 at Highmark Stadium. The Bills are undoubtedly the favorites in this one, with the spread posted at 15.5 points. The over/under is set at 48.5 in the outing.
The Saints lost to the Seattle Seahawks, 44-13, in their last contest.
Saints quarterback Spencer Rattler was 28-for-39 for 218 yards, with one TD and one INT, versus the Seahawks.
Last time around, the Bills defeated the Miami Dolphins, with 31-21 being the final score.
Saints vs Bills betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 8:31 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Buffalo (-15.5)Moneyline: Buffalo (-1429), New Orleans (+819)Total: 48.5 pointsSaints betting insightsLast year away from home, New Orleans was 3-5 against the spread and 2-6 overall.The Saints have not won a game against the spread this season (0-3-0).In four of eight away games last year, New Orleans went over the total.Saints games have gone over the total twice this season.Saints leadersRattler: 639 PASS YDS / 213 YPG / 67.2% / 4 TD / 1 INT / 10 CAR / 53 RUSH YDS / 0 TDAlvin Kamara: 50 CAR / 186 YDS / 62 YPG / 1 TD / 9 REC / 47 YDS / 15.7 YPG / 0 TDKendre Miller: 17 CAR / 59 YDS / 19.7 YPG / 0 TD / 3 REC / 11 YDS / 3.7 YPG / 0 TDJuwan Johnson: 19 REC / 176 YDS / 58.7 YPG / 1 TDChris Olave: 23 REC / 165 YDS / 55 YPG / 0 TDRashid Shaheed: 14 REC / 127 YDS / 42.3 YPG / 1 TDSaints vs Bills game infoDate: Sunday, September 28, 2025Time: 1 p.m. ETCity: Orchard Park, New YorkVenue: Highmark StadiumTV channel: CBSLive stream: Watch on Fubo (Regional restrictions may apply)Live stream: Watch on Paramount+ (Regional restrictions may apply)
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