The Buffalo Bills (3-0) host the New Orleans Saints (0-3) on Sunday at 1 p.m. ET, in a battle featuring a pair of the best offensive performers in the NFL in James Cook and Juwan Johnson.
With 302 total yards per game on offense, the Saints rank 19th in the NFL in 2025. Defensively, they rank 15th, giving up 313.3 total yards per contest. The Bills rank ninth in total defense this season (287.3 yards allowed per game), but they’ve been shining on the offensive side of the ball, ranking best in the NFL with 420 total yards per game.
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Saints vs Bills: Live streaming info, TV channel & game timeGame day: Sunday, September 28, 2025Game time: 1 p.m. ETLocation: Orchard Park, New YorkStadium: Highmark StadiumTV channel: CBSLive stream: Watch on Fubo! (Regional restrictions may apply)Live stream: Watch on Paramount+! (Regional restrictions may apply)
Watch Buffalo Bills vs. New Orleans Saints on Fubo! (Regional restrictions may apply)
Saints vs Bills betting lines
NFL odds courtesy of BetMGM. Odds updated Sunday at 12:29 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Bills (-14.5)Moneyline: Bills (-1429), Saints (+818)Total: 48.5 points
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