The Jacksonville Jaguars and the San Francisco face off in Week 4 of the NFL regular season. Here’s where to watch and start time.

The Jacksonville Jaguars are heading west this week for a road matchup with the San Francisco 49ers.

The Jaguars are coming off a late win over the Houston Texans to improve to 2-1 on the season, while the 49ers remain undefeated at 3-0 and will be getting quarterback Brock Purdy back as well.

This game is expected to provide the Jaguars with their toughest test of the season up to this point.

For some added insight into this 49ers team, you can find that here. To see who the NFL experts are picking to win this game, check here.

Here’s how you can watch Jaguars vs. 49ers in Week 4 of the NFL regular season.

Stream Jaguars vs. 49ers (free trial)

What TV channel is Jaguars vs. 49ers on today?TV channel: FOXStreaming: ESPN+ | Fubo (free trial)

Streaming options for the game include the ESPN app, ESPN+ and Fubo, which offers a free trial.

Jaguars vs. 49ers start timeWhen: Sunday, Sept. 28Time: 4:05 PM ETWhere: Levi’s Stadium, Santa Clara, CAJaguars tickets

Looking to buy Jacksonville Jaguars tickets? We’ve got you covered.

Buy Jacksonville Jaguars tickets

Jaguars vs. 49ers betting odds, moneyline, over/underJaguars regular-season schedule 2025

Below is Jacksonville’s regular-season schedule.