The Buffalo Bills look to stay unbeaten and take control of the AFC East when they take on the New England Patriots on Sunday Night Football. Buffalo is coming off a 31-19 win over the New Orleans Saints, while New England rolled to a 42-13 win over the Carolina Panthers in Week 4. The Patriots (2-2), who are 1-0 within the division, are also 1-0 on the road in 2025. The Bills (4-0), who are 2-0 in the division, are 3-0 on their home field.

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Kickoff from Highmark Stadium in Orchard Park, N.Y., is set for 8:20 p.m. ET. The Patriots lead the all-time series 79-51-1, but the Bills have won eight of the past 11 meetings. Buffalo is an 8.5-point favorite in the latest Patriots vs. Bills odds from SportsLine consensus, while the over/under for total points scored is set at 49.5. Buffalo is a -440 favorite on the money line (risk $440 to win $100), while New England is at +340 (risk $100 to win $340).

Before making any Patriots vs. Bills picks or NFL predictions, you NEED to hear what SportsLine football expert Mike Tierney has to say.

A veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, Mike Tierney is 235-189-13 in the NFL the past three seasons, returning $2,505 to $100 players. He hit 61.2% of his ATS picks (61-39-3) last season. He is also 26-14-3 (+1072) on his last 43 picks involving Buffalo Bills games. Anyone who has followed him could be WAY up!

Now, Tierney has analyzed Patriots vs. Bills from every angle and just locked in his picks and predictions.

We can tell you he’s leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

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