What we’re hearing on the Patriots: An unexpected injury issue popped up with one of the Patriots’ best players, as starting DT Milton Williams was added to the injury report Wednesday as a limited participant because of his ankle. Then Williams didn’t practice Thursday. He has played 72% of the defensive snaps through four games, has two sacks and has consistently created interior pressure. If he doesn’t play, that could thrust Khyiris Tonga into a starting role next to Christian Barmore. — Mike Reiss

What we’re hearing on the Bills: How will the rushing offense, which has been key to start the season, respond to the challenge the Patriots’ defense presents? RB James Cook has led Buffalo on the ground and has 100-plus yards in three straight games. New England, however, is tied for second in opponent rushing yards per game (77.5) and yards per rush (3.3). “[Cook] has such a really good understanding of what we’re trying to do, and how the guys are blocking and reading it. And he’s really special right now,” offensive coordinator Joe Brady said. — Alaina Getzenberg

Stat to know: Bills QB Josh Allen has 45 career games with both a passing touchdown and a rushing touchdown, tied with Cam Newton for the most by any player in NFL history. — ESPN Research

Bold prediction: Patriots rookie RB TreVeyon Henderson will record 64 or more rushing yards, doubling his current career high. Bills opponents have recorded a minus-14% pass rate over expectation this season, by far the lowest in the league. The Bills’ defense induces opponents’ runs. — Walder

Fantasy nugget: Bills TE Dalton Kincaid continues to split snaps and routes with others in the position group. You want to prioritize him in favorable matchups, like this week’s, which features one of the highest point totals on the slate. Kincaid catches passes from Allen in a Bills offense that ranks second in total yards per game. He faces a defense that gives up the ninth-most fantasy points per game to tight ends. See Week 5 rankings. — Moody

Betting nugget: The Patriots have covered four straight meetings with two outright wins as underdogs.

Maldonado’s pick: Bills 38, Patriots 24

Moody’s pick: Bills 34, Patriots 24

Walder’s pick: Bills 31, Patriots 27

FPI prediction: BUF, 67.5% (by an average of 7.2 points)