Buffalo (4-0) rides a four-game winning streak into a matchup with New England (2-2) on Sunday, October 5, 2025 at Highmark Stadium. The Bills are significant favorites in this one, with the spread posted at 8 points. The over/under is 49.5 in the outing.
Facing the Carolina Panthers in their last game, the Patriots won 42-13.
In that game against the Panthers, Pats quarterback Drake Maye completed 14 of 17 attempts for 203 yards, with two touchdowns and no interceptions.
The Bills’ last game was against the New Orleans Saints, and they won by a score of 31-19.
Patriots vs Bills betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 9:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Buffalo (-8)Moneyline: Buffalo (-431), New England (+335)Total: 49.5 pointsPatriots betting insightsLast season on the road, New England was 4-5 against the spread and 2-7 overall.The Patriots are 2-2-0 against the spread this season.New England had one win ATS (1-1) as 8-point underdogs or more away from home.In four of nine road games last year, New England went over the total.Patriots games have gone over the total twice this year.Patriots leadersMaye: 988 PASS YDS / 247.0 YPG / 74% / 7 TD / 2 INT / 24 CAR / 98 RUSH YDS / 2 TDRhamondre Stevenson: 31 CAR / 125 YDS / 31.3 YPG / 0 TD / 11 REC / 141 YDS / 35.3 YPG / 0 TDStefon Diggs: 19 REC / 213 YDS / 53.3 YPG / 0 TDHunter Henry: 15 REC / 204 YDS / 51.0 YPG / 3 TDKayshon Boutte: 10 REC / 165 YDS / 41.3 YPG / 1 TDPatriots vs Bills game infoDate: Sunday, October 5, 2025Time: 8:20 p.m. ETCity: Orchard Park, New YorkVenue: Highmark StadiumTV channel: NBCLive stream: Watch on Fubo (Regional restrictions may apply)Live stream: Watch on Peacock
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