At Highmark Stadium on Sunday, James Cook and the Buffalo Bills (4-0) play Drake Maye and the New England Patriots (2-2) in a battle between a pair of the biggest stars in the NFL offensively, beginning at 8:20 p.m. ET.
The Bills own the ninth-ranked defense this year (290 yards allowed per game), and they’ve been better on offense, ranking second-best with 404 yards per game. The Patriots are putting up 336.3 total yards per contest on offense this season (14th-ranked). Meanwhile, they are allowing 319 total yards per game (16th-ranked).
Watch Buffalo Bills vs. New England Patriots on Fubo! (Regional restrictions may apply)
Bills vs Patriots: live streaming info, TV channel & game timeGame day: Sunday, October 5, 2025Game time: 8:20 p.m. ETLocation: Orchard Park, New YorkStadium: Highmark StadiumTV channel: NBCLive stream: Watch on Fubo! (Regional restrictions may apply)Live stream: Watch on Peacock!
Watch Buffalo Bills vs. New England Patriots on Fubo! (Regional restrictions may apply)
Bills vs Patriots betting lines
NFL odds courtesy of BetMGM. Odds updated Sunday at 12:22 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Bills (-8)Moneyline: Bills (-431), Patriots (+335)Total: 49.5 points
Watch Buffalo Bills vs. New England Patriots on Fubo! (Regional restrictions may apply)