NFL Week 3 predictions: Why we picked Colts, 49ers, and Falcons
If you need help with your NFL picks this week, Lorenzo is here with his three best bets ahead of Sunday’s Week 3 games.
Lorenzo’s Locks
The Atlanta Falcons and Carolina Panthers play on Sunday, Sept. 21, at the Panthers’ Bank of America Stadium in a game on the NFL Week 3 schedule.
Which team will win the NFL Week 3 game?
Check out these NFL Week 3 picks and NFL Week 3 predictions for the game, which can be seen at 10 a.m. MST on FOX (stream with FUBO).
The Falcons are a 6-point favorite over the Panthers in NFL Week 3 odds for the game, courtesy of BetMGM Sportsbook.
Atlanta is -275 on the moneyline, while Carolina is +220. The over/under (point total) is set at 43.5 points.
NFL Week 3 picks: Dolphins at Bills | Falcons at Panthers | Packers at Browns | Texans at Jaguars | Bengals at Vikings | Steelers at Patriots | Rams at Eagles | Jets at Buccaneers | Colts at Titans | Raiders at Commanders | Broncos at Chargers | Saints at Seahawks | Cowboys at Bears | Cardinals at 49ers | Chiefs at Giants | Lions at Ravens | The Republic’s score predictions
Watch Falcons at Panthers live on FUBO (free trial)
Jeremy Cluff writes: “Bijan Robinson and Tyler Allgeier are starting to form one of the NFL’s best 1-2 running back punches for the Falcons. They will prove too much for the Panthers to handle, dropping Carolina to 0-3.”
Bookies.com: Bet the Panthers to cover vs Falcons
Bill Speros writes: “Unfortunately, these teams play each other twice a year. There are leaves to be raked.”
The site’s formula predicts that the Falcons will win the NFL Week 3 game against the Panthers.
ESPN: Falcons have a 56.9% chance to beat Panthers on Sunday
The site gives the Panthers a 42.8% shot at winning the NFL Week 3 game, with the remaining percentage accounting for a tie.
Dimers: Panthers 24, Falcons 22
It writes: “After extensive simulations, our model gives the Falcons a win probability of 45%, while the Panthers have a win probability of 55%.”
Sportsnaut: Falcons 24, Panthers 17
Matt Johnson writes: “The Atlanta Falcons’ defense demonstrated on Sunday Night Football that it can be a force to be reckoned with at times, which is a huge turnaround from what it has been over the last five years. As for the Carolina Panthers, while they’ve made improvements at stopping the run, Bijan Robinson just demonstrated against Minnesota that ‘bad’ matchups don’t matter to him. Carolina will keep this game competitive, but Atlanta is well-rounded enough now to come out on top of these winnable games.”
NFL’s highest paid players in 2025: Quarterbacks | Running backs | Wide receivers | Tight ends | Offensive linemen | D-linemen | Cornerbacks | Safeties | Linebackers | Edge rushers | Highest paid NFL players: Overall | By position | By team
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
Support local journalism: Subscribe to azcentral.com today.