In a Week 6 NFL schedule that features plenty of compelling matchups, the San Francisco 49ers versus the Tampa Bay Buccaneers is a game to catch.
Take a peek at our betting preview for the NFL’s Week 6.
Week 6 NFL games: betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Tuesday at 11:37 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
ThursdayPhiladelphia Eagles at New York Giants odds and lines
The Philadelphia Eagles take on the New York Giants at 8:15 p.m. ET on Thursday at MetLife Stadium in East Rutherford, New Jersey.
Favorite: Eagles (-7.5)Total: 40.5Moneyline: Eagles (-391) | Giants (+306)TV channel: Amazon Prime VideoLive stream: Watch on Prime VideoSundayDenver Broncos at New York Jets odds and lines
The Denver Broncos square off against the New York Jets at 9:30 a.m. ET on Sunday at Tottenham Hotspur Stadium in London, England.
Favorite: Broncos (-7.5)Total: 43.5Moneyline: Broncos (-398) | Jets (+313)TV channel: NFL NetworkLive stream: Watch on Fubo (Regional restrictions may apply)Los Angeles Chargers at Miami Dolphins odds and lines
The Los Angeles Chargers hit the field against the Miami Dolphins at 1 p.m. ET on Sunday at Hard Rock Stadium in Miami Gardens, Florida.
Favorite: Chargers (-4.5)Total: 43Moneyline: Chargers (-223) | Dolphins (+184)TV channel: CBSLive stream: Watch on Fubo (Regional restrictions may apply)Arizona Cardinals at Indianapolis Colts odds and lines
The Arizona Cardinals will play the Indianapolis Colts at 1 p.m. ET on Sunday at Lucas Oil Stadium in Indianapolis, Indiana.
Favorite: Colts (-6.5)Total: 47.5Moneyline: Colts (-309) | Cardinals (+247)TV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)Seattle Seahawks at Jacksonville Jaguars odds and lines
The Seattle Seahawks will play the Jacksonville Jaguars at 1 p.m. ET on Sunday at EverBank Stadium in Jacksonville, Florida.
Favorite: Jaguars (-1.5)Total: 46.5Moneyline: Jaguars (-120) | Seahawks (+100)TV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)New England Patriots at New Orleans Saints odds and lines
The New England Patriots square off against the New Orleans Saints at 1 p.m. ET on Sunday at Caesars Superdome in New Orleans, Louisiana.
Favorite: Patriots (-3.5)Total: 46Moneyline: Patriots (-192) | Saints (+158)TV channel: CBSLive stream: Watch on Fubo (Regional restrictions may apply)Dallas Cowboys at Carolina Panthers odds and lines
The Dallas Cowboys will square off against the Carolina Panthers at 1 p.m. ET on Sunday at Bank of America Stadium in Charlotte, North Carolina.
Favorite: Cowboys (-3.5)Total: 49.5Moneyline: Cowboys (-183) | Panthers (+152)TV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)Los Angeles Rams at Baltimore Ravens odds and lines
The Los Angeles Rams match up with the Baltimore Ravens at 1 p.m. ET on Sunday at M&T Bank Stadium in Baltimore, Maryland.
Favorite: Rams (-7.5)Total: 44.5Moneyline: Rams (-398) | Ravens (+309)TV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)Cleveland Browns at Pittsburgh Steelers odds and lines
The Cleveland Browns will meet the Pittsburgh Steelers at 1 p.m. ET on Sunday at Acrisure Stadium in Pittsburgh, Pennsylvania.
Favorite: Steelers (-5.5)Total: 38.5Moneyline: Steelers (-252) | Browns (+205)TV channel: CBSLive stream: Watch on Fubo (Regional restrictions may apply)Tennessee Titans at Las Vegas Raiders odds and lines
The Tennessee Titans will match up with the Las Vegas Raiders at 4:05 p.m. ET on Sunday at Allegiant Stadium in Paradise, Nevada.
Favorite: Raiders (-4.5)Total: 41.5Moneyline: Raiders (-237) | Titans (+194)TV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)San Francisco 49ers at Tampa Bay Buccaneers odds and lines
The San Francisco 49ers play the Tampa Bay Buccaneers at 4:25 p.m. ET on Sunday at Raymond James Stadium in Tampa, Florida.
Favorite: Buccaneers (-3)Total: 47.5Moneyline: Buccaneers (-161) | 49ers (+135)TV channel: CBSLive stream: Watch on Fubo (Regional restrictions may apply)Cincinnati Bengals at Green Bay Packers odds and lines
The Cincinnati Bengals will square off against the Green Bay Packers at 4:25 p.m. ET on Sunday at Lambeau Field in Green Bay, Wisconsin.
Favorite: Packers (-14)Total: 44.5Moneyline: Packers (-1099) | Bengals (+685)TV channel: CBSLive stream: Watch on Fubo (Regional restrictions may apply)Detroit Lions at Kansas City Chiefs odds and lines
The Detroit Lions play the Kansas City Chiefs at 8:20 p.m. ET on Sunday at GEHA Field at Arrowhead Stadium in Kansas City, Missouri.
Favorite: Chiefs (-2.5)Total: 52.5Moneyline: Chiefs (-137) | Lions (+115)TV channel: NBCLive stream: Watch on Fubo (Regional restrictions may apply)MondayBuffalo Bills at Atlanta Falcons odds and lines
The Buffalo Bills will play the Atlanta Falcons at 7:15 p.m. ET on Monday at Mercedes-Benz Stadium in Atlanta, Georgia.
Favorite: Bills (-4.5)Total: 49.5Moneyline: Bills (-224) | Falcons (+184)TV channel: ESPNLive stream: Watch on Fubo (Regional restrictions may apply)Chicago Bears at Washington Commanders odds and lines
The Chicago Bears will match up with the Washington Commanders at 8:15 p.m. ET on Monday at Northwest Stadium in Landover, Maryland.
Favorite: Commanders (-4.5)Total: 50Moneyline: Commanders (-227) | Bears (+187)TV channel: ABCLive stream: Watch on Fubo (Regional restrictions may apply)