Lions vs. Buccaneers prediction, pick, odds for Monday's NFL Week 7 game

Lions vs. Buccaneers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 9:16 p.m.

Moneyline (ML): Detroit -285 (Bet $285 to win $100) | Tampa Bay +230 (Bet $100 to win $230)Against the spread (ATS): Detroit -5.5 (-115) | Tampa Bay +5.5 (-105)Over/Under (O/U): 52.5 (O: -110 | U: -110)Lions vs. Buccaneers betting tips preview

Best bets are available for when the Detroit Lions (4-2) host the Tampa Bay Buccaneers (5-1) at Ford Field on Monday, October 20, 2025.

The Lions last played against the Kansas City Chiefs, and they fell short 30-17. The Buccaneers picked up a 30-19 win last time out when they took on the 49ers. Last time out for the Lions, Jared Goff finished with 23 completions on 29 attempts (79.3%) for 203 yards, tossing two touchdowns. Jahmyr Gibbs carried the ball 17 times for 65 yards. Jameson Williams hauled in six passes for 66 yards with one touchdown.

In the Buccaneers’ last game, Baker Mayfield threw for 256 yards on 17-23 passing (73.9%), adding two touchdowns. Rachaad White ran for one touchdown while totaling 65 yards on 17 attempts. He also hauled in three receptions for 21 yards. Kameron Johnson gained 64 yards on four receptions with one score.

Watch Detroit Lions vs. Tampa Bay Buccaneers on Fubo! (Regional restrictions may apply)

Lions vs. Buccaneers key injuriesLionsCB Terrion Arnold (shoulder) limited participation in practiceLB Zach Cunningham (hamstring) full participation in practiceOT Taylor Decker (shoulder) limited participation in practiceS Kerby Joseph (knee) did not participate in practiceCB Avonte Maddox (hamstring) did not participate in practiceDL Alim McNeill (knee) full participation in practiceDL D.J. Reader (back) limited participation in practiceRB Sione Vaki (groin) did not participate in practiceBuccaneersLB Lavonte David (knee) did not participate in practiceP Riley Dixon (personal) full participation in practiceWR Emeka Egbuka (hamstring) did not participate in practiceWR Mike Evans (hamstring) did not participate in practiceWR Chris Godwin (fibula) did not participate in practiceOT Luke Haggard (shoulder) did not participate in practiceRB Bucky Irving (foot) did not participate in practiceCB Zyon McCollum (thumb) full participation in practiceCB Benjamin Morrison (hamstring) full participation in practiceRB Josh Williams (concussion) did not participate in practiceLions vs. Buccaneers prediction

Buccaneers 28, Lions 26

Moneyline pick: Buccaneers +230The Lions have a 74.0% chance to win this matchup based on the moneyline’s implied probability.Detroit has not yet lost a game it was the moneyline favorite this season, going 3-0.The Lions have played in three games as a moneyline favorite with odds of -285 or shorter and won each time.Tampa Bay has entered the game as an underdog three times this season and won twice.The Buccaneers have not entered a game this season with longer moneyline odds than +230.Pick ATS: Buccaneers (+5.5)Detroit has posted a 4-2-0 record against the spread this season.The Lions have been favored by 5.5 points or more three times this season and have covered the spread in all of them.In Tampa Bay’s six games this year, it has four wins against the spread.Pick OU: Over (52.5)In three of six games this season, the Lions and their opponents have scored more than 52.5 points.The Buccaneers have played three games this season that have gone over 52.5 combined points scored.These teams rack up 59.3 points per game between them, 6.8 more than this game’s over/under.Combined, these teams give up 48.9 points per game, 3.6 fewer points than this matchup’s total.

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Lions vs. Buccaneers prediction, pick, odds for Monday’s NFL Week 7 game

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