The Detroit Lions (4-2) are 5.5-point favorites heading into their matchup on Monday, October 20, 2025 against the Tampa Bay Buccaneers (5-1).

Lions vs. Buccaneers game infoGame day: Monday, October 20, 2025Game time: 7 p.m. ETTV channel: ABC/ESPNLocation: Detroit, MichiganStadium: Ford FieldLive stream: Watch this game on Fubo (Regional restrictions may apply)

Watch Detroit Lions vs. Tampa Bay Buccaneers on Fubo! (Regional restrictions may apply)

Lions vs. Buccaneers odds & betting linesSpread favorite: Detroit (-5.5)Moneyline: Detroit (-276), Tampa Bay (+222)Total: 52.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Friday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Lions vs. Buccaneers recent matchupsIn the last five meetings between the Lions and Buccaneers, Detroit has gone 3-2.The two teams each scored 108 total points over the course of those five games.Lions vs. Buccaneers betting insightsDetroit, in six games with a spread this season, has gone 4-2-0 against the spread. In three games as a moneyline favorite, the Lions are 3-0. Tampa Bay is 4-2-0 against the spread in six opportunities so far this season. The Buccaneers have been the moneyline underdog three times this year, going 2-1 in those games.Lions scoring insightsThe Lions’ scoring average at home, 43.0 points per game, is better than their average away, 26.3.Defensively, Detroit is giving up 15.5 points per game at home, better than its 27.8 average on the road.The Lions rank seventh in scoring offense (29.3 points per game) and 10th in scoring defense (21.3 points per game allowed) over their last three games.Buccaneers scoring insightsAt home, the Buccaneers’ scoring average is 28.0 points per game, which is slightly better than their average on the road, 27.0.On defense, Tampa Bay is allowing 25.7 points per game at home, slightly worse than its 24.7 average on the road.The Buccaneers are third-best in the NFL in points scored for the past three games (31.0 per game) and fifth-worst in points conceded (28.3).Lions injury reportLions:
D.J. Reader: Limited Participation in Practice (Back),
Avonte Maddox: Did Not Participate In Practice (Hamstring),
Kerby Joseph: Did Not Participate In Practice (Knee),
Terrion Arnold: Limited Participation in Practice (Shoulder),
Alim McNeill: Full Participation in Practice (Knee),
Zach Cunningham: Full Participation in Practice (Hamstring),
Taylor Decker: Limited Participation in Practice (Shoulder),
Sione Vaki: Did Not Participate In Practice (Groin)Buccaneers injury reportBuccaneers:
Luke Haggard: Did Not Participate In Practice (Shoulder),
Chris Godwin: Did Not Participate In Practice (Fibula),
Mike Evans: Did Not Participate In Practice (Hamstring),
Emeka Egbuka: Did Not Participate In Practice (Hamstring),
Riley Dixon: Full Participation in Practice (Personal),
Lavonte David: Did Not Participate In Practice (Knee),
Josh Williams: Did Not Participate In Practice (Concussion),
Benjamin Morrison: Full Participation in Practice (Hamstring),
Zyon McCollum: Full Participation in Practice (Thumb),
Bucky Irving: Did Not Participate In Practice (Foot)

Watch Detroit Lions vs. Tampa Bay Buccaneers on Fubo! (Regional restrictions may apply)