The Indianapolis Colts (6-1) hold the NFL’s best record. The Tennessee Titans (1-6) have a better mark than only the winless New York Jets.

So you figure the Colts would be heavy home favorites in NFL Week 8 action. But this heavy?

The Colts open as 14-point favorites for their game at Lucas Oil Stadium.

The last time the Colts were such large favorites, they blew a season. In the 2021 season finale, Indianapolis was a 15-point favorite heading to Jacksonville. The formula was simple: The Colts win and they make the playoffs; the Jaguars lose and they clinch the No. 1 overall pick in the 2022 NFL Draft.

Jacksonville won 26-11 as the Colts — who had a 98% chance to make the playoffs with two weeks remaining — missed out on the postseason.

The Colts beat the Titans 41-20 in Nashville in Week 3 behind Jonathan Taylor‘s three rushing touchdowns (to be fair, he has done that three times this season).

Are the Colts favored over the Titans on Sunday, Oct. 26, in NFL Week 8? Colts-Titans betting oddsvia BetMGMFavorite: Colts by 14 pointsOver/under: 45.5 total pointsMoneyline: Colts -1200, Titans +750Colts tickets for sale; Colts vs. Titans tickets

Colts-Titans tickets range from $56-$719 on StubHub.

Find Colts vs. Titans tickets on StubHub

(All times ET)Thursday, Oct. 23: Minnesota Vikings at Los Angeles Chargers, 8:15 p.m., Amazon (summary, box score)Sunday, Oct. 26: Miami Dolphins at Atlanta Falcons, 1 p.m., CBS (summary, box score)Sunday, Oct. 26: Chicago Bears at Baltimore Ravens, 1 p.m., CBS (summary, box score)Sunday, Oct. 26: Buffalo Bills at Carolina Panthers, 1 p.m., Fox (summary, box score)Sunday, Oct. 26: New York Jets at Cincinnati Bengals, 1 p.m., CBS (summary, box score)Sunday, Oct. 26: San Francisco 49ers at Houston Texans, 1 p.m., Fox (summary, box score)Sunday, Oct. 26: Cleveland Browns at New England Patriots, 1 p.m., Fox (summary, box score)Sunday, Oct. 26: New York Giants at Philadelphia Eagles, 1 p.m., Fox (summary, box score)Sunday, Oct. 26: Tampa Bay Buccaneers at New Orleans Saints, 4:05 p.m., Fox (summary, box score)Sunday, Oct. 26: Dallas Cowboys at Denver Broncos, 4:25 p.m., CBS (summary, box score)Sunday, Oct. 26: Tennessee Titans at Indianapolis Colts, 4:25 p.m., CBS (summary, box score)Sunday, Oct. 26: Green Bay Packers at Pittsburgh Steelers, 8:20 p.m., NBC, Peacock, NBC Universo (summary, box score)Monday, Oct. 27: Washington Commanders at Kansas City Chiefs, 8:15 p.m., ABC, ESPN, ESPN2, ESPN Deportes (summary, box score)Who has a bye in Week 8?Week 1: Indianapolis Colts 33, Miami Dolphins 8, box score, statsWeek 2: Colts 29, Denver Broncos 28, box score, statsWeek 3: Colts 41, Tennessee Titans 20, box score, statsWeek 4: Los Angeles Rams 27, Colts 20, box score, statsWeek 5: Colts 40, Las Vegas Raiders 6, box score, statsWeek 6: Colts 31, Arizona Cardinals 27, box score, statsWeek 7: Colts 38, Los Angeles Chargers 24, box score, statsWeek 8: Sunday, Oct. 26, vs. Tennessee Titans, 4:25 p.m., CBSWeek 9: Sunday, Nov. 2, at Pittsburgh Steelers, 1 p.m., CBSWeek 10: Sunday, Nov. 9, vs. Atlanta Falcons in Berlin, Germany, 9:30 a.m., NFL NetworkWeek 11: ByeWeek 12: Sunday, Nov. 23, at Kansas City Chiefs, 1 p.m., CBSWeek 13: Sunday, Nov. 30, vs. Houston Texans, 1 p.m., CBSWeek 14: Sunday, Dec. 7, at Jacksonville Jaguars, 1 p.m., CBSWeek 15: Sunday, Dec. 14, at Seattle Seahawks, 4:25 p.m., CBSWeek 16: Monday, Dec. 22, vs. San Francisco 49ers, 8:15 p.m., ESPN‘s “Monday Night Football”Week 17: Sunday, Dec. 28, vs. Jacksonville Jaguars, 1 p.m., FoxWeek 18: Date TBD, at Houston Texans, time TBD, TBD

Joel A. Erickson covers the Colts all season. Get more coverage on IndyStarTV and with the Colts Insider newsletter.