The Indianapolis Colts (6-1) take a three-game winning streak into their contest with the Tennessee Titans (1-6) on Sunday, October 26, 2025 at Lucas Oil Stadium. The Colts are heavy favorites in this one, with the line posted at 14.5 points. The over/under is 48 in the contest.
Against the New England Patriots in their most recent contest, the Titans lost 31-13.
In that matchup versus the Patriots, Titans quarterback Cameron Ward completed 25 of 34 attempts for 255 yards, with one touchdown and one interception.
The Colts won versus the Los Angeles Chargers in their most recent game, 38-24.
Titans vs Colts betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 5:15 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Indianapolis (-14.5)Moneyline: Indianapolis (-1471), Tennessee (+842)Total: 48 pointsTitans betting insightsIn away games, Tennessee has two wins against the spread and is 1-3 overall.The Titans have put together a record of 2-5-0 against the spread this year.In four road games this season, Tennessee has hit the over once.Games involving Titans have hit the over four times this season.Titans leadersWard: 1,356 PASS YDS / 193.7 YPG / 57.6% / 4 TD / 5 INTTony Pollard: 98 CAR / 380 YDS / 54.3 YPG / 2 TD / 17 REC / 122 YDS / 17.4 YPG / 0 TDTyjae Spears: 14 CAR / 67 YDS / 22.3 YPG / 0 TD / 7 REC / 37 YDS / 12.3 YPG / 0 TDCalvin Ridley: 16 REC / 290 YDS / 48.3 YPG / 0 TDElic Ayomanor: 19 REC / 225 YDS / 32.1 YPG / 2 TDChigoziem Okonkwo: 23 REC / 218 YDS / 31.1 YPG / 0 TDTitans vs Colts game infoDate: Sunday, October 26, 2025Time: 4:25 p.m. ETCity: Indianapolis, IndianaVenue: Lucas Oil StadiumTV channel: CBSLive stream: Watch on Fubo (Regional restrictions may apply)Live stream: Watch on Paramount+ (Regional restrictions may apply)
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