Indianapolis (6-1) rides a three-game winning streak into a matchup with Tennessee (1-6) on Sunday, October 26, 2025 at Lucas Oil Stadium. The Colts are undoubtedly the favorites in this one, with the spread sitting at 14.5 points. The over/under in the contest is set at 48 points.
Last time around, the Colts defeated the Los Angeles Chargers, with 38-24 being the final score.
The Colts’ Daniel Jones went 23-for-34 for 288 yards versus the Chargers, with two TDs and no INTs.
The Titans lost to the New England Patriots, 31-13, in their most recent contest.
Colts vs Titans betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 5:07 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Indianapolis (-14.5)Moneyline: Indianapolis (-1471), Tennessee (+842)Total: 48 pointsColts betting insightsIndianapolis is 3-1 against the spread, and 4-0 overall, at home.The Colts have covered the spread five times in seven games with a set spread.This year, in four home games, Indianapolis has hit the over twice.This season, Colts games have hit the over four times.Colts leadersJones: 1,790 PASS YDS / 255.7 YPG / 71% / 10 TD / 3 INT / 29 CAR / 83 RUSH YDS / 4 TDJonathan Taylor: 131 CAR / 697 YDS / 99.6 YPG / 10 TD / 23 REC / 185 YDS / 26.4 YPG / 1 TDTyler Warren: 33 REC / 439 YDS / 62.7 YPG / 3 TDMichael Pittman Jr.: 35 REC / 351 YDS / 50.1 YPG / 5 TDAlec Pierce: 16 REC / 317 YDS / 63.4 YPG / 0 TDColts vs Titans game infoDate: Sunday, October 26, 2025Time: 4:25 p.m. ETCity: Indianapolis, IndianaVenue: Lucas Oil StadiumTV channel: CBSLive stream: Watch on Fubo (Regional restrictions may apply)Live stream: Watch on Paramount+ (Regional restrictions may apply)
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