Two of the top offensive players in the league will be on display when Travis Kelce and the Kansas City Chiefs (5-3) visit James Cook and the Buffalo Bills (5-2) on Sunday, November 2, 2025.
The Bills’ offense has been dominant, putting up 29.6 points per game (fourth-best) this season. On defense, they rank ninth by surrendering 20.9 points per game. The Chiefs have been thriving on both offense and defense, ranking fifth-best in total offense (378.3 yards per game) and fourth-best in total defense (277.8 yards allowed per game).
Watch Kansas City Chiefs vs. Buffalo Bills on Fubo! (Regional restrictions may apply)
Bills vs Chiefs: Live streaming info, TV channel & game timeGame day: Sunday, November 2, 2025Game time: 4:25 p.m. ETLocation: Orchard Park, New YorkStadium: Highmark StadiumTV channel: CBSLive stream: Watch on Fubo! (Regional restrictions may apply)Live stream: Watch on Paramount+! (Regional restrictions may apply)
Watch Kansas City Chiefs vs. Buffalo Bills on Fubo! (Regional restrictions may apply)
Bills vs Chiefs betting lines
NFL odds courtesy of BetMGM. Odds updated Sunday at 12:23 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Chiefs (-1.5)Moneyline: Chiefs (-131), Bills (+110)Total: 52.5 points
Watch Kansas City Chiefs vs. Buffalo Bills on Fubo! (Regional restrictions may apply)