On Sunday at 4:25 p.m. ET, two excellent receivers will be on display when Puka Nacua and the Los Angeles Rams (6-2) visit Christian McCaffrey and the San Francisco 49ers (6-3).
The Rams enter the matchup after winning 34-10 over the New Orleans Saints in their last game on Nov. 2. The 49ers’ last game finished in a 34-24 win over the New York Giants. Matthew Stafford had 281 yards on 24-of-32 passing (75.0%) for the Rams in that matchup against the Saints, with four touchdowns and no interceptions. Kyren Williams took 25 carries for 114 yards (4.6 yards per carry) and one touchdown. Nacua recorded seven receptions for 95 yards (averaging 13.6 per catch), while scoring one touchdown against the Saints. Mac Jones’ showing for the Niners against the Giants included 19-of-24 passing for 235 yards, two touchdowns and no interceptions. In that matchup, McCaffrey had a 28-carry, 106-yard game (3.8 yards per attempt) with one touchdown. He also added five receptions for 67 yards and one touchdown. Jauan Jennings collected four catches for 41 yards (on five targets), with one touchdown.
We dig deep into all of the details you need before this matchup begins in this article, including how to watch on Fubo.
Watch Los Angeles Rams vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)
Rams vs. 49ers game infoGame day: Sunday, November 9, 2025Game time: 4:25 p.m. ETLocation: Santa Clara, CaliforniaStadium: Levi’s StadiumTV channel: FOX (KNIN-Boise, ID)Live stream: Fubo (Watch Now!)
Watch Los Angeles Rams vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)
Rams vs. 49ers betting info
NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 11:05 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Rams (-4.5)Moneyline: Rams (-220), 49ers (+180)Total: 49.5 points
Watch Los Angeles Rams vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)