The Seattle Seahawks will once again take on the Arizona Cardinals in 2025, which will be their first NFC West rematch of the season. Seattle has won the last eight-straight games over Arizona in a stretch of unprecedented dominance in this rivalry. However, when these teams meet at Lumen Field, the game is often a little more competitive than when it is played down in the Valley of the Sun.
Can the Seahawks keep the momentum going after such a dominant performance last week against the Washington Commanders? Or will they suffer a setback with another home loss? Seahawks Wire has you covered with our predictions, as well as betting information and predictions from Cards Wire managing editor Jess Root. For more information, please read on!
Odds courtesy of BetMGM as of Saturday, November 8th, 2025
Spread: Seahawks -7Over/under: 45.5Moneyline: Seahawks -340Seahawks vs Cardinals predictions, picks for NFL Week 10Kole Musgrove – Seahawks Wire Managing Editor
Seahawks 23, Cardinals 17: Seahawks-Cardinals games are always odd, sluggish, chaotic outings, especially when these teams meet in Seattle. The last three meetings have been decided by scores of 16-6, 20-10 and 19-9. I think Seattle’s offense, following their literally perfect performance last week, slows down a bit against a division opponent. Sudden health concerns, such as Jarran Reed’s absence, could keep the Cardinals technically in the game a bit longer than the 12th Man may be comfortable with. I’m taking the Seahawks in a defensive affair that will end up not feeling as competitive as the final score might suggest.
Dom Skene – Seahawks Wire Contributor
Seahawks 29, Cardinals 17: Walter Nolen can give the Seahawks IOL fits, and Jacoby Brissett will give Marvin Harrison Jr a chance to be the playmaker on Arizona’s offense- but the healthy Seahawks defense will roll, with captains Drake Thomas and Mike Morris exceeding expectations in increased opportunities.
Jess Root – Cards Wire Managing Editor
Seahawks 31, Cardinals 13: Seattle is going to be too much. Even likely missing Ernest Jones, the run game will be non-existent, which means play action won’t do anything. Brissett gets sacked four times and turns the ball over twice.
Seahawks vs Cardinal time, TV channel todayTV Channel: CBSLivestream: Fubo (free trial) and Paramount+Date:Â Sunday, November 9thStart time:Â 1:05 PM Pacific Time