The San Francisco 49ers (6-4) will face off against NFC West rivals, the Arizona Cardinals (3-6), on Sunday, November 16, 2025 at State Farm Stadium. The 49ers are listed as favorites in this one, with the spread sitting at 3.5 points. The over/under for the contest is 48.5 points.
The 49ers’ last contest was versus the Los Angeles Rams, and they lost by a score of 42-26.
In that game versus the Rams, Niners quarterback Mac Jones completed 33 of 39 passes for 319 yards, with three touchdowns and one interception.
Against the Seattle Seahawks in their last game, the Cardinals lost 44-22.
49ers vs Cardinals betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 8:47 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: San Francisco (-3.5)Moneyline: San Francisco (-191), Arizona (+158)Total: 48.5 points49ers betting insightsOn the road, San Francisco is 4-2 overall and 4-2 against the spread.The 49ers are 5-5-0 against the spread this season.This season, in six road games, San Francisco has gone over the total four times.This season, six 49ers games have gone over the point total.49ers leadersBrock Purdy: 586 PASS YDS / 293.0 YPG / 65.8% / 4 TD / 4 INT / 7 CAR / 30 RUSH YDS / 0 TDChristian McCaffrey: 180 CAR / 626 YDS / 62.6 YPG / 4 TD / 69 REC / 692 YDS / 69.2 YPG / 4 TDBrian Robinson Jr.: 49 CAR / 238 YDS / 23.8 YPG / 2 TD / 6 REC / 15 YDS / 1.5 YPG / 0 TDKendrick Bourne: 31 REC / 482 YDS / 53.6 YPG / 0 TDRicky Pearsall: 20 REC / 327 YDS / 81.8 YPG / 0 TD49ers vs Cardinals game infoDate: Sunday, November 16, 2025Time: 4:05 p.m. ETCity: Glendale, ArizonaVenue: State Farm StadiumTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)
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