The San Francisco 49ers face the Arizona Cardinals in Week 11 of the NFL season on Sunday at State Farm Stadium.

How to Watch 49ers vs CardinalsWhen: Sunday, November 16, 2025Time: 4:05 PM ETTV Channel: FOXLive Stream: Fubo (try for free)

The San Francisco 49ers come in as the stronger team, with a balanced offense that leans on their rushing and efficient short-to-intermediate passing game. Mac Jones has been leading the charge, but Brock Purdy returns to the lineup, and a healthy Christian McCaffrey has given them a reliable weapon both on the ground and through the air. On defense, losing Nick Bosa to a season-ending knee injury has been a big blow, but the 49ers are relying on younger pass-rushers to step up and their front seven to generate pressure and close running lanes. Their ability to limit explosive plays and take advantage in tight spots has carried them so far.

For the Arizona Cardinals, it’s a challenging spot. Their offense has been hampered by the absence of Kyler Murray, and they’ll need to lean on their running backs and tight ends to sustain drives. Trey McBride has the potential to be a mismatched threat, and the Cardinals’ backfield could be more involved than ever. On defense, Arizona needs to step up in big moments. They’ve shown flashes in coverage, but stopping San Francisco’s playmakers will be critical. If the Cardinals can control the clock and avoid turnovers, they could make this game interesting; otherwise, the 49ers may pull away late.

This is a great NFL matchup that you will not want to miss; make sure to tune in and catch all the action.

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