Brendan O’Sullivan provides his top player prop bets for Sunday’s Buffalo Bills vs. Tampa Bay Buccaneers matchup.

Week 11 features a matchup between the Bills and Buccaneers, both of whom are 6-3 this season. Despite the same record, these opponents are in different positions in their respective conferences.

The Bills are trailing the Patriots in the AFC East, thus owning a Wild Card spot, while the Buccaneers are atop the NFC South.

Buffalo is a 5.5-point favorite and -250 on the moneyline, while Tampa Bay is +205 on DraftKings Sportsbook. The game total is set at 47.5 points.

Here are my favorite player props for this Week 11 NFL game between the Bills and Buccaneers.

Bills vs. Buccaneers Best Prop Bets

James Cook anytime touchdown (-185)

Let’s start with an easy one. James Cook is one of the best running backs in the league and has been a consistent touchdown scorer each week. He has seven touchdowns in nine games just a year after scoring 16 times.

It’s also a solid matchup for him as the Buccaneers allow the eighth most rushing touchdowns to running backs this year. Tampa Bay is better at slowing down quarterback rushing touchdowns, allowing just one on the season.

The Bills should lean on Cook rather than Josh Allen in the run game because of this. Yes, it’s a hefty price for a single bet, but it could slot in as a leg of a parlay.

Rachaad White over 45.5 rushing yards (-115)

Bucky Irving is out yet again, leaving Rachaad White as the starting running back this week. White is a quality backup that is active in both the run and pass games. It’s beneficial for Baker Mayfield, who is without a couple key receivers.

White has filled in nicely and will continue to have a big role until the Buccaneers’ offense is fully healthy. Although he’s been solid in the pass game, I prefer his rushing prop because that’s a major weakness for Buffalo.

The Bills allow the third most rushing yards in the NFL, and White has double-digit carries in his last five games. With so many offensive weapons injured, White should have a major role in this matchup.

Baker Mayfield over 1.5 passing touchdowns (+119)

The Buccaneers are dealing with many key injuries on offense, yet Mayfield keeps chugging away. He looks like an MVP candidate through the first half of the season and has the Buccaneers in a playoff spot.

The Bills are a tough matchup, especially on the road, but Mayfield is hard to bet against. I initially sided with under 1.5 passing touchdowns, but Mayfield has recorded at least two passing touchdowns in six of nine games this season.

Since Irving is out, Mayfield will need to take on even more responsibility. White is a serviceable back and will get a good chunk of carries, but he won’t beat the Bills on his own. If the Buccaneers want to win, it’ll be due to Mayfield’s excellence.