The Indianapolis Colts (8-2) visit the Kansas City Chiefs (5-5) at GEHA Field at Arrowhead Stadium in Kansas City for a Week 12 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, November 23, including live updated odds and injury report news.
NameWeek 102025 SeasonJon Hoefling7-884-77-3Blake Schuster11-483-65-3Tyler Dragon6-982-79-3Chris Bumbaca11-478-83-3Lorenzo Reyes6-977-86-3Jordan Mendoza7-864-68-2Richard MorinN/A25-12-1Chiefs vs. Colts live odds, moneyline, over/under
Opening Lines
Spread: Chiefs (-9.5)Moneyline: Chiefs (-455), Colts (+350)Over/Under: 45.5
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Chiefs vs. Colts picks against the spreadJon Hoefling: Indianapolis Colts (+3.5)
Coming off a bye, it’s hard for me to back the Chiefs, even though I do believe they will still reach the playoffs and eventually the AFC Championship Game.
Jordan Mendoza: Indianapolis Colts (+3.5)
Indianapolis wants to prove its legitimacy while Kansas City needs to show it isn’t done yet. This is a close battle that comes to a field goal.
Lorenzo Reyes: Kansas City Chiefs (-3.5)
Andy Reid’s Chiefs teams tend to be lethal coming off of losses, so I think you’ll find a hyper-focused team, especially since their grasp on a playoff berth may be slipping away. The Colts are coming off their bye, but I have to back KC at Arrowhead here.
Tyler Dragon: Kansas City Chiefs (-3.5)
This is a must-win game for the 5-5 Chiefs. The AFC West division is probably out of reach, but a playoff berth isn’t.
Blake Schuster: Indianapolis Colts (+3.5)
The Chiefs bounce back and win this one, but Indianapolis keeps it close enough to cover.
Christopher Bumbaca: Kansas City Chiefs (-3.5)
The Chiefs can’t go below .500, right? Interested to see this Colts offense operate outdoors in KC.
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