The Jacksonville Jaguars (6-4) visit the Arizona Cardinals (3-7) at State Farm Stadium in Glendale for a Week 12 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, November 23, including live updated odds and injury report news.
NameWeek 102025 SeasonJon Hoefling7-884-77-3Blake Schuster11-483-65-3Tyler Dragon6-982-79-3Chris Bumbaca11-478-83-3Lorenzo Reyes6-977-86-3Jordan Mendoza7-864-68-2Richard MorinN/A25-12-1Cardinals vs. Jaguars live odds, moneyline, over/under
Opening Lines
Spread: Cardinals (-3)Moneyline: Cardinals (-162), Jaguars (+136)Over/Under: 47.5
Get the edge with our exclusive NFL betting picks
Cardinals vs. Jaguars picks against the spreadJon Hoefling: Jacksonville Jaguars (-2.5)
In what world do the Cardinals have a chance here? 2.5 points is minuscule.
Jordan Mendoza: Arizona Cardinals (+2.5)
This one has trap game written all over it for the Jaguars. They may get caught surprise by the pass-heavy offense of Arizona.
Lorenzo Reyes: Jacksonville Jaguars (-2.5)
The Jaguars throttled the Chargers, and I think this is a generous line at under a field goal. I like Jacksonville here quite a bit.
Tyler Dragon: Jacksonville Jaguars (-2.5)
The Jaguars ran all over the Chargers last week. I think Jacksonville will carry that momentum into Arizona.
Blake Schuster: Jacksonville Jaguars (-2.5)
These Jaguars are impossible. Just when you want to write them off, they knock off the Chargers at home. This week it’s Jacksonville flying across the country, but the afternoon start should help.
Christopher Bumbaca: Arizona Cardinals (+2.5)
The Jacksonville Jaguars in the Eastern Time Zone? I think they’re the best team in the AFC South. I’ll happily fade them anywhere else though.
Cardinals vs. Jaguars updated injury reportNFL Week 12 picks, predictions, oddsSuper Bowl 60 updated odds