The Buffalo Bills (7-3) visit the Houston Texans (5-5) at NRG Stadium in Houston for a Week 12 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Thursday, November 20, including live updated odds and injury report news.
NameWeek 102025 SeasonJon Hoefling7-884-77-3Blake Schuster11-483-65-3Tyler Dragon6-982-79-3Chris Bumbaca11-478-83-3Lorenzo Reyes6-977-86-3Jordan Mendoza7-864-68-2Richard MorinN/A25-12-1Texans vs. Bills live odds, moneyline, over/under
Opening Lines
Spread : Bills (-3.5)Moneyline: Bills (-192), Texans (+154)Over/Under: 46.5
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Texans vs. Bills picks against the spreadJon Hoefling: Buffalo Bills (-5.5)
With C.J. Stroud unlikely to play once again, it’s hard to imagine a world where Houston keeps this game within a touchdown.
Jordan Mendoza: Houston Texans (+5.5)
It’ll be a great battle to see if Houston’s defense can contain Buffalo. The Texans are able to hang around to give the offense a shot.
Lorenzo Reyes: Buffalo Bills (-5.5)
This is a matchup of strength on strength, but I think it’s the continued absence of C.J. Stroud that puts Buffalo ahead. The Bills can score points, so I think – even with Houston’s defense being as solid as it is – the visitors cover here.
Tyler Dragon: Buffalo Bills (-5.5)
C.J. Stroud is still in concussion protocol. Stroud’s absence eliminates Houston’s chance at an upset.
Blake Schuster: Buffalo Bills (-5.5)
Have you seen Davis Mills play football? You could give him a month to prep for this game and I’d still take Buffalo at any number.
Christopher Bumbaca: Buffalo Bills (-5.5)
The Texans’ goal line issues are the opposite of how the Bills operate. Even with a formidable defensive front, the Bills should be too much.
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