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The Indianapolis Colts (8-2) are considered favorites (-8.5) according to the bookmakers ahead of their game against the Kansas City Chiefs (5-5) on November 23, 2025, starting at 1 p.m. ET, airing on CBS. The predicted point total for the matchup is 45.5.
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Colts vs. Chiefs Odds & Betting Lines Colts vs Chiefs Betting Information updated as of November 21, 2025, 11:33 p.m. ET. Favorite Spread Favorite Spread Odds Underdog Spread Odds Total Over Total Odds Under Total Odds Colts -8.5 425 -730 45.5 -195 144
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Colts vs. Chiefs Prediction & PickPick ATS: Chiefs (+8.5)
Pick OU: Over (45.5)
Prediction: Colts 25 – Chiefs 24How to Watch Indianapolis vs. Kansas CityGame date: Sunday, November 23, 2025Time: 1 p.m. ETVenue: GEHA Field at Arrowhead StadiumLocation: Kansas City, MissouriTV: CBSLive Boxscore: FOX SportsColts vs. Chiefs Recent MatchupsIndianapolis owns a 3-1 record against Kansas City in their last four matchups.Over their last four head-to-head contests, Kansas City has put up 89 points, while Indianapolis has accumulated 87.Indianapolis Betting InfoIndianapolis has played 10 games, posting six wins against the spread.The Colts have been favored by 8.5 points or more two times this season, and covered the spread in one of those contests.Indianapolis games this year have gone over the total in six out of 10 opportunities (60%).The Colts have won 85.7% of the time they have played as the moneyline favorite (6-1).Based on this game’s moneyline, the Colts’ implied win probability is 39.4%.Colts Stats Stat Average (Total) Rank Pass yards 251.6 (2,516) 3 Rush yards 145.3 (1,453) 3 Points scored 32.1 (321) 1 Pass yards against 235.3 (2,353) 25 Rush yards against 92.3 (923) 5 Points allowed 20.6 (206) 9 Indianapolis’ Key PlayersOffenseJonathan Taylor’s rushing output this season includes 1,139 yards (first in the NFL) and 15 TDs. He’s averaging 113.9 yards per game and 6 per attempt (first in the NFL).Taylor has 32 targets, 30 receptions, 260 receiving yards and two TDs through the air.Daniel Jones has thrown for 2,659 yards (fourth in the NFL), 15 touchdowns and seven interceptions this year. He is averaging 265.9 yards per game and 8.3 per attempt, while completing 69.9%.He’s rushed for 143 yards (second on the Colts) and added five touchdowns on the ground, while averaging 14.3 rushing yards per game.Michael Pittman Jr. has six touchdown catches this season (eighth in the NFL), and has 54 catches for 580 yards on 70 targets, while averaging 5.4 catches and 58 yards per game.Tyler Warren has put up 617 receiving yards and three touchdowns with 50 catches on 67 targets. He’s averaging five receptions and 61.7 yards per game.DefenseOn the defensive side, Nick Cross has 69 tackles, four TFL, 2.5 sacks, and one interception in 2025.Zaire Franklin has 60 tackles, three TFL, and two sacks this season. He’s third on the Colts in tackles.Laiatu Latu has recorded 26 tackles, six TFL, five sacks, and two interceptions this year.This season, Germaine Pratt has 63 tackles and three TFL.Kansas City Betting InfoKansas City is 5-5-0 against the spread this year.This year, three Kansas City games have gone over the point total.The Chiefs have split the two games they’ve played as underdogs this season.The moneyline for this contest implies a 64.9% chance of a victory for the Chiefs.Chiefs Stats Stat Average (Total) Rank Pass yards 248.9 (2,489) 5 Rush yards 115.3 (1,153) 16 Points scored 25.4 (254) 11 Pass yards against 196.8 (1,968) 11 Rush yards against 100.0 (1,000) 9 Points allowed 18.1 (181) 4 Kansas City’s Key PlayersOffensePatrick Mahomes is averaging 7.3 passing yards per attempt (12th in the NFL) and 262.5 yards per game this year, completing 64.5% of his passes on the way to 2,625 total yards (fifth in the NFL), 18 touchdowns (seventh in the NFL) and six interceptions through 10 games.Mahomes has also rushed for four touchdowns and 288 yards (third on the Chiefs).Travis Kelce has put together a 2025 stat sheet that includes 50 catches for 631 yards and four receiving touchdowns in 10 games played. He has been on the receiving end of 66 targets and is averaging five receptions per game.Kareem Hunt has rushed for six touchdowns this year, and has totaled 353 rushing yards (35.3 per game and 4.1 per carry).Hunt’s stat sheet includes 10 receptions (1 per game) on 13 targets for 66 yards (6.6 per game) and one receiving touchdown.Marquise Brown has been targeted 57 times, resulting in 38 catches for 429 yards .DefenseSo far in 2025, Nick Bolton has amassed 81 tackles and five TFL over 10 games.Chamarri Conner has one sack in addition to his one TFL and 70 tackles over 10 games.George Karlaftis III has 35 tackles, eight TFL, five sacks, and two passes defended during the 2025 season.Trent McDuffie has put up one sack to go with two TFL, 50 tackles, and one interception through 10 games.
FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.
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