The Jacksonville Jaguars (6-4) square off against the Arizona Cardinals (3-7) on Sunday, November 23, 2025 at State Farm Stadium. The line predicts a close game, with the Jaguars favored by 2.5 points. The over/under is 47.5 in the contest.
Facing the Los Angeles Chargers in their last game, the Jaguars won 35-6.
Against the Chargers, Trevor Lawrence completed 14 of 22 passes for 153 yards, with one touchdown and one interception, for the Jags.
The Cardinals lost against the San Francisco 49ers in their most recent game, 41-22.
Jaguars vs Cardinals betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 5:39 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Jacksonville (-2.5)Moneyline: Jacksonville (-149), Arizona (+125)Total: 47.5 pointsJaguars betting insightsJacksonville is 2-2 overall, with only one win against the spread, in away games.The Jaguars have registered a 5-5-0 record against the spread this season.The Jaguars have a perfect 1-0 ATS record when playing as at least 2.5-point favorites.In four away games this year, Jacksonville has gone over the total every time.Jaguars games have finished with a final combined score above the over/under five times this season.Jaguars leadersLawrence: 2,151 PASS YDS / 215.1 YPG / 59.8% / 11 TD / 8 INT / 49 CAR / 181 RUSH YDS / 5 TDTravis Etienne: 154 CAR / 729 YDS / 72.9 YPG / 5 TD / 21 REC / 130 YDS / 13 YPG / 1 TDBhayshul Tuten: 60 CAR / 238 YDS / 23.8 YPG / 3 TD / 8 REC / 61 YDS / 6.1 YPG / 1 TDJakobi Meyers: 41 REC / 457 YDS / 50.8 YPG / 0 TDBrian Thomas: 30 REC / 420 YDS / 52.5 YPG / 1 TDParker Washington: 30 REC / 350 YDS / 35 YPG / 2 TDJaguars vs Cardinals game infoDate: Sunday, November 23, 2025Time: 4:05 p.m. ETCity: Glendale, ArizonaVenue: State Farm StadiumTV channel: CBSLive stream: Watch on Fubo (Regional restrictions may apply)Live stream: Watch on Paramount+ (Regional restrictions may apply)
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