The Kansas City Chiefs (5-5) will face off against the Indianapolis Colts (8-2) on Sunday, November 23, 2025 at GEHA Field at Arrowhead Stadium. The Chiefs are listed as favorites in this one, with the spread sitting at 3.5 points. An over/under of 49.5 points has been set for the outing.
The Chiefs lost to the Denver Broncos, 22-19, in their most recent game.
Against the Broncos, Patrick Mahomes completed 29 of 45 passes for 276 yards, with one touchdown and one interception, for the Chiefs.
In their last game, the Colts won versus the Atlanta Falcons, 31-25.
Chiefs vs Colts betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Sunday at 12:23 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Kansas City (-3.5)Moneyline: Kansas City (-184), Indianapolis (+153)Total: 49.5 pointsChiefs betting insightsKansas City is 4-1 against the spread, and 4-1 overall, at home.The Chiefs have covered the spread five times over 10 games with a set spread.At home, Kansas City is unbeaten ATS (2-0) as 3.5-point favorites or greater.The Chiefs have an ATS record of 3-2 when playing as at least 3.5-point favorites.Kansas City has hit the over once in five home games this season.Chiefs games have gone over the total three times this season.Chiefs leadersMahomes: 2,625 PASS YDS / 262.5 YPG / 64.5% / 18 TD / 6 INT / 48 CAR / 288 RUSH YDS / 4 TDKareem Hunt: 86 CAR / 353 YDS / 35.3 YPG / 6 TD / 10 REC / 66 YDS / 6.6 YPG / 1 TDIsiah Pacheco: 78 CAR / 329 YDS / 41.1 YPG / 1 TD / 11 REC / 43 YDS / 5.4 YPG / 1 TDTravis Kelce: 50 REC / 631 YDS / 63.1 YPG / 4 TDMarquise Brown: 38 REC / 429 YDS / 42.9 YPG / 4 TDTyquan Thornton: 15 REC / 372 YDS / 46.5 YPG / 3 TDChiefs vs Colts game infoDate: Sunday, November 23, 2025Time: 1 p.m. ETCity: Kansas City, MissouriVenue: GEHA Field at Arrowhead StadiumTV channel: CBSLive stream: Watch on Fubo (Regional restrictions may apply)Live stream: Watch on Paramount+ (Regional restrictions may apply)
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