The Arizona Cardinals (3-7) will look to upset the Jacksonville Jaguars (6-4) on Sunday, November 23, 2025 at State Farm Stadium. The line foreshadows a close game, with the Jaguars favored by 2.5 points. The over/under is 47.5 in the contest.
In their last game, the Cardinals lost against the San Francisco 49ers, 41-22.
Against the 49ers, Jacoby Brissett completed 47 of 57 attempts for 452 yards, with two touchdowns and two interceptions, for the Cards.
Against the Los Angeles Chargers in their most recent contest, the Jaguars won 35-6.
Cardinals vs Jaguars betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Sunday at 12:59 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Jacksonville (-2.5)Moneyline: Jacksonville (-138), Arizona (+116)Total: 47.5 pointsCardinals betting insightsArizona has covered the spread once at home, and is 1-4 overall there this season.The Cardinals have covered the spread five times over 10 games with a set spread.At home, Arizona has one win ATS (1-1) as 2.5-point underdogs or greater.The Cardinals are 3-2 ATS when playing as at least 2.5-point underdogs.In five home games this season, Arizona has gone over the total four times.Cardinals games have gone over the total six times this season.Cardinals leadersBrissett: 1,570 PASS YDS / 224.3 YPG / 66.7% / 10 TD / 3 INT / 21 CAR / 80 RUSH YDS / 1 TDEmari Demercado: 31 CAR / 241 YDS / 30.1 YPG / 0 TD / 8 REC / 64 YDS / 8.0 YPG / 1 TDBam Knight: 53 CAR / 181 YDS / 22.6 YPG / 3 TD / 12 REC / 86 YDS / 10.8 YPG / 0 TDTrey McBride: 71 REC / 718 YDS / 71.8 YPG / 7 TDMarvin Harrison Jr.: 34 REC / 525 YDS / 58.3 YPG / 4 TDMichael Wilson: 37 REC / 416 YDS / 41.6 YPG / 1 TDCardinals vs Jaguars game infoDate: Sunday, November 23, 2025Time: 4:05 p.m. ETCity: Glendale, ArizonaVenue: State Farm StadiumTV channel: CBSLive stream: Watch on Fubo (Regional restrictions may apply)Live stream: Watch on Paramount+ (Regional restrictions may apply)
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