One of the top receivers in the league will be on display when Christian McCaffrey and the San Francisco 49ers (7-4) host the Carolina Panthers (6-5) on Monday, November 24, 2025.
The Panthers are accumulating 314.3 total yards per contest on offense this season (22nd-ranked). Meanwhile, they are surrendering 325.9 total yards per game (18th-ranked). The 49ers are putting up 23.7 points per game on offense this season (15th in NFL), and they are allowing 22.9 points per game (16th) on the other side of the ball.
Watch San Francisco 49ers vs. Carolina Panthers on Fubo! (Regional restrictions may apply)
Panthers vs 49ers: Live streaming info, TV channel & game timeGame day: Monday, November 24, 2025Game time: 8:15 p.m. ETLocation: Santa Clara, CaliforniaStadium: Levi’s StadiumTV channel: ESPNLive stream: Watch on Fubo! (Regional restrictions may apply)
Watch San Francisco 49ers vs. Carolina Panthers on Fubo! (Regional restrictions may apply)
Panthers vs 49ers betting lines
NFL odds courtesy of BetMGM. Odds updated Monday at 12:21 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: 49ers (-7.5)Moneyline: 49ers (-385), Panthers (+303)Total: 49.5 points
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