The San Francisco 49ers (8-4) visit the Cleveland Browns (3-8) at Huntington Bank Field in Cleveland for a Week 13 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, November 30, including live updated odds and injury report news.
NameWeek 122025 SeasonJon Hoefling5-8-189-85-4Blake Schuster4-9-187-74-4Tyler Dragon6-7-188-86-4Chris Bumbaca5-8-183-91-4Lorenzo Reyes5-8-182-92-4Jordan Mendoza4-9-168-77-3Richard MorinN/A25-12-1Browns vs. 49ers live odds, moneyline, over/under
Opening Lines
Spread: 49ers (-6)Moneyline: 49ers (-258), Browns (+205)Over/Under: 42.5
Get the edge with our exclusive NFL betting picks
Browns vs. 49ers picks against the spreadTyler Dragon: San Francisco 49ers (-5.5)
Shedeur Sanders gets a well-deserved second start. The 49ers will be the toughest test of his young career.
Jon Hoefling: San Francisco 49ers (-5.5)
The Niners have won two straight games by double digits and the Browns might be the weakest team they’ve faced during that stretch. Despite Clevelands incredible defense, I expect Brock Purdy to bounce back.
Blake Schuster: San Francisco 49ers (-5.5)
Shedeur Sanders was serviceable in his first start. Now he gets to face a Niners defense that just shredded Bryce Young and the Panthers. This spread might be too small.
Jordan Mendoza: San Francisco 49ers (-5.5)
Shedeur Sanders had a nice first career start, but it’s not going to be as fun dealing with the 49ers defense.
Lorenzo Reyes: Cleveland Browns (+5.5)
I think this is a case where Cleveland’s defense keeps this game closer. Still, I think the Niners will have a better plan against Shedeur Sanders, so I would hit the under here.
Richard Morin: Cleveland Browns (+5.5)
Neither team is inspiring much confidence at present. Brock Purdy is coming off a three-interception performance (albeit in a winning effort).
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