The Cleveland Browns (3-8) are 4.5-point underdogs heading into their matchup on Sunday, November 30, 2025 against the San Francisco 49ers (8-4).

49ers vs. Browns game infoGame day: Sunday, November 30, 2025Game time: 1 p.m. ETTV channel: CBSLocation: Cleveland, OhioStadium: Huntington Bank FieldLive stream: Watch this game on Fubo (Regional restrictions may apply)Live stream: Watch this game on Paramount+ (Regional restrictions may apply)

Watch San Francisco 49ers vs. Cleveland Browns on Fubo! (Regional restrictions may apply)

49ers vs. Browns odds & betting linesSpread favorite: San Francisco (-4.5)Moneyline: San Francisco (-240), Cleveland (+198)Total: 36.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 2:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

49ers vs. Browns recent matchupsCleveland and San Francisco have split their last two matchups (1-1).San Francisco scored 48 points in those two matchups, with Cleveland putting up 22.49ers vs. Browns betting insightsSan Francisco has seven wins against the spread so far this season (7-5-0). The 49ers have been favored on the moneyline eight times this season, and they are 7-1 in those games. Cleveland is 5-6-0 against the spread this season. The Browns have a 2-7 record this year in games they have been the moneyline underdog.49ers scoring insightsThe 49ers’ scoring average at home, 20.6 points per game, is worse than their average away, 25.4.Defensively, San Francisco is giving up 20.4 points per game at home, less than its 22.7 average away from home.The 49ers average more points in division games (25.2) than against the rest of the league (22.1).San Francisco has given up 23.0 points per game in the division, which is higher than its average outside the division of 20.9.The 49ers rank 24th in the NFL with 24.3 points per game allowed on defense over the previous three games, but they’ve really been rolling on the offensive side of the ball, as they rank fourth-best with 29.0 points per game during that stretch.Browns scoring insightsAt home, the Browns score 18.6 points per game, higher than their 15.5 average away from home.Defensively, Cleveland is conceding 15.4 points per game at home, better than its 27.8 average on the road.On offense, the Browns average fewer points in division games (14.5) than outside the division (18.3).Cleveland has given up 26.0 points per game in the division, which is higher than its mark in non-division games of 20.0.Offensively in their previous three games, the Browns are averaging 20.0 points, 20th in the NFL. On defense, they are allowing 20.0, which places them eighth.49ers injury report49ers:
Trent Williams: Did Not Participate In Practice (Rest),
Brock Purdy: Full Participation in Practice (Toe),
Dominick Puni: Full Participation in Practice (Shoulder),
Eddy Pineiro: Did Not Participate In Practice (Hamstring),
Ricky Pearsall: Full Participation in Practice (Knee),
Sam Okuayinonu: Did Not Participate In Practice (Ankle),
Christian McCaffrey: Did Not Participate In Practice (Rest),
Luke Gifford: Limited Participation in Practice (Hip),
Tatum Bethune: Did Not Participate In Practice (Ankle),
Robert Beal: Full Participation in Practice (Concussion)Browns injury reportBrowns:
Denzel Ward: Did Not Participate In Practice (Migraine),
Alex Wright: Did Not Participate In Practice (Quad),
Jamari Thrash: Limited Participation in Practice (Foot),
Carson Schwesinger: Limited Participation in Practice (Ankle),
David Njoku: Limited Participation in Practice (Knee),
Myles Garrett: Limited Participation in Practice (Rest),
Adin Huntington: Did Not Participate In Practice (Quad),
Ronnie Hickman: Limited Participation in Practice (Rest),
Dillon Gabriel: Full Participation in Practice (Concussion),
Jerome Ford: Limited Participation in Practice (Hamstring),
Grant Delpit: Limited Participation in Practice (Rest),
Maliek Collins: Limited Participation in Practice (Rest),
Tyson Campbell: Limited Participation in Practice (Hip),
Devin Bush Jr.: Limited Participation in Practice (Rest),
Joel Bitonio: Limited Participation in Practice (Rest),
Brenden Bates: Did Not Participate In Practice (Ankle)

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