The Jacksonville Jaguars welcome the Indianapolis Colts to Everbank Stadium on Sunday. With both teams looking to separate themselves at the top of the AFC South, here are three battles to keep an eye on:

Jourdan Lewis vs Tyler Warren

After a blistering start to the season was cruelly interrupted by injury, Jourdan Lewis returned against the Tennessee Titans last weekend. Whilst he had a quiet afternoon versus an ineffective passing game, just making it through the contest was a boost for the Jaguars. With the secondary getting healthy, Lewis looks set to man the nickel spot against the Indianapolis Colts this Sunday.

If the Titans game was ‘easing back in’ to action, then the matchup against Indy is much more of a live drill; Lewis will be expected to keep rookie sensation Tyler Warren in check. Tight end Warren has been everything promised and more coming out of Penn State, with 58 catches, 684 yards and four scores already in his NFL career. The Colts will look to him and Jonathan Taylor to move the chains, and use outside targets Alec Pierce and Michael Pittman for splash plays.

The Colts will be looking to bounce back after two straight losses. If Lewis can erase Warren from the equation the likelihood of making that three defeats on the bounce goes up considerably.

Jakobi Meyers vs Charvarius Ward

With the loss of Travis Hunter to injury, the midseason trade for Jakobi Meyers appears to have paid dividends for the 8-4 Jaguars. Sunday was Meyers’ best performance for Jacksonville to date, leading the team with 90 yards and a touchdown from six receptions. With Brian Thomas enduring something of a sophomore slump, the introduction of Meyers has kept the passing attack alive – and he’ll be hoping to have a similar impact against the Colts this weekend.

Meyers may have been facing Sauce Gardner had injury not ruled out Indy’s star corner; Gardner suffered a calf strain that will sideline him at least for Week 13 and probably longer. Fears he could be done for the season were unfounded, but it does mean Charvarius Ward becomes the CB1 in the Colts’ secondary.

Ward has only played six games this year due to a concussion, a frustrating start to life in Indianapolis after signing in free agency. His 21 tackles on the season highlight this lack of action, but the cornerback is heating up and had a strong performance against the Houston Texans last weekend. The industrious Meyers will be keen to test Ward early and often – no easy task.

Trevor Lawrence vs Daniel Jones

It’s not been the smoothest of seasons for Trevor Lawrence. The Jaguars’ franchise quarterback has struggled throughout the campaign to be fully on the same page as Liam Coen, with moments of frustration from both QB and head coach well documented. But could Sunday have been a turning point? Lawrence seemed to have more time in the pocket, and despite still taking three sacks was surgical from within the pocket, throwing for 229 yards and two scores. Crucially there was an absence of turnovers too, whilst his scrambling ability was also on show – a much welcome performance for a slightly concerned fanbase.

Conversely, Daniel Jones has found some form in 2025 that the rest of his career has not suggested he possessed. The former New York Giants and Minnesota Vikings quarterback has come alive in Shane Steichen’s offense, helping the Colts to be one of the in-form teams through the first half of the year.

Unfortunately for Jones his last two weeks haven’t quite hit the same standard as he battles through injury; a fractured fibula impacting his ability to plant and deliver from the pocket. He’s also been less mobile and able to move the chains with his legs. Despite the ailment, Jones has still been able to play mistake-free football – and he certainly wasn’t the reason for the Colts dropping their last two games and falling behind the Jags in the AFC South.

It’s not a sentence I’d ever thought I’d write; before this year I would have just assumed it was a given. But if Lawrence can outshine Jones on Sunday, the Jags might just widen the gap at the top of the division.