The Tennessee Titans (2-11) visit the San Francisco 49ers (9-4) at Levi’s Stadium in Santa Clara for a Week 15 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, December 14, including live updated odds and injury report news.
NameWeek 142025 SeasonBlake Schuster9-5108-82-5Jon Hoefling9-5104-99-5Tyler Dragon5-8100-102-5Chris BumbacaN/A83-91-4Lorenzo Reyes8-597-105-5Jordan Mendoza3-1179-95-4Richard Morin5-937-29-249ers vs. Titans live odds, moneyline, over/under
Opening Lines
Spread: 49ers (-7.5)Moneyline: 49ers (-360), Titans (+285)Over/Under: 45.5
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49ers vs. Titans picks against the spreadBlake Schuster: San Francisco 49ers -(12.5)
I might almost be tempted to take the Titans here if this game were in Tennessee. The key word being “almost”.
Jon Hoefling: Tennessee Titans (+12.5)
The 49ers aren’t as good as their record indicates. I expect them to win, but they are 0-2 against the AFC South thus far this year.
Tyler Dragon: San Francisco 49ers -(12.5)
San Francisco won three straight games and will make it four in a row.
Jordan Mendoza: San Francisco 49ers -(12.5)
San Francisco has won three straight games by at least 11 points. With a young Tennessee team coming in, the 49ers push it to four straight dominant wins.
Christopher Bumbaca: San Francisco 49ers -(12.5)
Snap back to reality for the Titans. Christian McCaffrey should have a field day against that defense.
Lorenzo Reyes: San Francisco 49ers -(12.5)
San Francisco was on its bye and the Titans simply don’t have the star talent to compete with this Niners roster. Don’t let a win against Cleveland fool you.
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