NFC South rivals meet when the Carolina Panthers (7-6) visit the New Orleans Saints (3-10) on Sunday, December 14, 2025 at Caesars Superdome. Carolina is favored by 2.5 points.

Panthers vs. Saints game infoGame day: Sunday, December 14, 2025Game time: 4:25 p.m. ETTV channel: FOXLocation: New Orleans, LouisianaStadium: Caesars SuperdomeLive stream: Watch this game on Fubo (Regional restrictions may apply)

Watch Carolina Panthers vs. New Orleans Saints on Fubo! (Regional restrictions may apply)

Panthers vs. Saints odds & betting linesSpread favorite: Carolina (-2.5)Moneyline: Carolina (-154), New Orleans (+129)Total: 40.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Panthers vs. Saints recent matchupsNew Orleans is 4-1 versus Carolina in the past five matchups between the two squads.In those matchups with the Panthers, the Saints went 3-2 against the spread, and those games outscored the total on two occasions.New Orleans put up 134 points in those five matchups, while Carolina posted 63.Panthers vs. Saints betting insightsCarolina has an 8-5-0 record against the spread so far this season. In one game as the moneyline favorite, the Panthers lost. New Orleans has five wins against the spread in 13 opportunities this season (5-8-0). The Saints are the moneyline underdog for the 12th game this year. They are 2-9 as an underdog.Panthers scoring insightsThe Panthers are averaging more points at home (22.3) than on the road (16.1).Defensively, Carolina is giving up 22.7 points per game at home, a little better than its 23.0 average away from home.The Panthers average more points in division games (22.3) than outside the division (18.0).Carolina is giving up 14.7 points per game in divisional matchups, which is better than its 25.3 average versus the rest of the league.The Panthers rank 14th in scoring offense (23.3 points per game) and 21st in scoring defense (25.0 points per game allowed) during their last three games.Saints scoring insightsAt home, the Saints are averaging fewer points (15.3) than on the road (16.3), but barely.Defensively, New Orleans is giving up 22.0 points per game at home, less than its 26.1 average on the road.On offense, the Saints average fewer points in division games (13.5) than against the rest of the league (16.9).New Orleans is giving up 18.5 points per game in divisional matchups, which is better than its 26.8 average outside the division.The Saints are 27th in the NFL in points scored for the past three games (17.0 per game) and 12th in points conceded (21.7).Panthers injury reportPanthers:
Christian Rozeboom: Full Participation in Practice (Hip),
Lathan Ransom: Full Participation in Practice (Thumb),
Cade Mays: Full Participation in Practice (Ankle),
Jaycee Horn: Full Participation in Practice (Concussion),
Claudin Cherelus: Full Participation in Practice (Concussion)Saints injury reportSaints:
Chris Rumph: Full Participation in Practice (Wrist),
Devin Neal: Limited Participation in Practice (Abdomen),
Taliese Fuaga: Limited Participation in Practice (Ankle),
Asim Richards: Did Not Participate In Practice (Ankle),
Justin Reid: Limited Participation in Practice (Knee),
Alvin Kamara: Did Not Participate In Practice (Knee),
Davon Godchaux: Did Not Participate In Practice (NIR – Rest)

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