Arizona Cardinals receiver Marvin Harrison Jr. (18) warms up before their game against the Detroit Lions at State Farm Stadium Glendale, Ariz., Sep 22, 2024. Syndication: Arizona Republic

GLENDALE – The Arizona Cardinals Week 15 injury report is a sad state of affairs. If being 3-10 wasn’t enough, Arizona enters this matchup with 13 players on the injury report, with eight of them being ruled out. The headliners are Marvin Harrison Jr. and Paris Johnson Jr. being out for the offense, while CB1 Max Melton will be in street clothes as well.

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Harrison is missing his fourth game in five weeks, while his Ohio State teammate Johnson is only missing his second game of the year. The offense looks for a rough Sunday against one of the elite defenses in the NFL without their top two guys.

Cardinals

Oct 19, 2025; Glendale, Arizona, USA; Arizona Cardinals offensive lineman Paris Johnson Jr. (70) against the Green Bay Packers at State Farm Stadium. Mandatory Credit: Mark J. Rebilas-Imagn Images

Full Cardinals injury report for Week 15:

OUT:

Jalen Thompson (Hamstring)
Marvin Harrison Jr. (Heel)
Paris Johnson Jr. (Knee)
Max Melton (Heel)
Dadrion Taylor-Demerson (Ankle)
Evan Brown (Personal)
Bilal Nichols (Knee)
Xavier Weaver (Hamstring)

QUESTIONABLE:

Walter Nolen (Knee)
Christian Jones (Knee)
Elijah Higgins (Illness)
Emari Demercado (Ankle)
L.J. Collier (Knee)

Cardinals

Nov 3, 2025; Arlington, Texas, USA; Arizona Cardinals defensive tackle Walter Nolen III (97) walks off the field after the game between the Dallas Cowboys and the Arizona Cardinals at AT&T Stadium. Mandatory Credit: Jerome Miron-Imagn Images

Nolen is the marquee name in the questionable section, as he complete changes the dynamic of the Cardinals front seven. The defense has struggled to stop the run and generate pressure in Nolen’s absence. If he suits up, the 22-year-old will rejuvenate the unit against a middling pass rush in Houston. In only four games, Nolen has a sack, interception and touchdown. His insertion is crucial for Arizona to end its five-game losing streak.

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Reporter Tanner Tortorella covers general assignment for Burn City Sports. You can follow him on his X account, @TannerTSports