The Kansas City Chiefs are preparing to host the Los Angeles Chargers on Sunday for a critical AFC West clash, widely labeled a must-win game for their playoff hopes.

The week has been dominated by negative availability updates severely impacting the Kansas City offense. On Friday, the Chiefs officially ruled out wide receiver Marquise “Hollywood” Brown (personal reasons), starting right guard Trey Smith (ankle), and right tackle Jawaan Taylor (triceps/knee).

Brown’s unexpected absence, combined with the continued unavailability of two Pro Bowl-caliber offensive linemen, forces rookie Esa Pole into a starting left tackle role and leaves the Chiefs dangerously thin on offense. Head coach Andy Reid noted Smith “worked through and pushed himself” but was “just not ready to go.”

This dramatic, multi-player injury and absence report prompted analysts to urgently reevaluate their Chiefs vs. Chargers predictions and offensive play projections. New simulations now factor in a drastically reshuffled offensive unit.

The results of these simulations were compared to updated sportsbook odds to compile the data-driven Chiefs-Chargers preview below.

Chargers vs. Chiefs betting preview

Utilize the interactive widget below to view the latest spread, total, and moneyline betting odds and probabilities for the Chargers-Chiefs game at GEHA Field at Arrowhead Stadium.

This prediction and best bet for Sunday’s NFL matchup between the Chargers and Chiefs is from Dimers.com, a dependable source for sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

The key information you need before the Chargers vs. Chiefs NFL game.

Teams: Los Angeles Chargers vs. Kansas City ChiefsDate: Sunday, December 14, 2025Kickoff: 1 p.m. ESTLocation: GEHA Field at Arrowhead StadiumNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

Odds for the key markets in the Chargers-Chiefs NFL contest.

Spread: Chargers +6 (-112), Chiefs -6 (-108)Moneyline: Chargers +215, Chiefs -250Total: Over/Under 41.5 (-110/-108)

The odds and lines presented here are the best available from selected sports betting sites at the time of publication and are subject to change.

Promos

New users in MO can take advantage of FanDuel’s special $300 launch promo.

Expert prediction: Chargers vs. Chiefs

Utilizing cutting-edge data analysis and advanced algorithms, the experts at Dimers have performed 10,000 simulations of Sunday’s Chargers vs. Chiefs matchup.

According to Dimers’ highly regarded predictive analytics model, the Chiefs are more likely to defeat the Chargers at GEHA Field at Arrowhead Stadium. This prediction is based on the model giving the Chiefs a 71% chance of winning the game.

Furthermore, Dimers predicts that the Chargers (+6) have a 51% chance of covering the spread, while the over/under total of 41.5 points has a 54% chance of going over.

As always, these predictions and probabilities are correct at the time of publication but are subject to potential changes.

Chargers vs. Chiefs best bet

Our top pick for the Chargers vs. Chiefs Week 15 NFL game is to bet on Over 41.5 points (-110).

This betting advice is based on comprehensive modeling and valuable wagering intelligence, designed to help you make smarter investments.

Score prediction for Chargers vs. Chiefs

Dimers’ projected final score for the LA Chargers vs. Kansas City game on Sunday has the Chiefs winning 23-18.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL player props: Sunday

NFL player prop bets are an enjoyable way to wager on Sunday’s game without necessarily betting on its outcome.

This article features the most likely first and anytime touchdown scorers for the Chargers and Chiefs, along with projected player stats.

Los Angeles ChargersFirst touchdown scorer predictionsOmarion Hampton: 7.9% probabilityLadd McConkey: 6.0% probabilityQuentin Johnston: 5.1% probabilityAnytime touchdown predictionsOmarion Hampton: 36.0% probabilityLadd McConkey: 28.5% probabilityQuentin Johnston: 24.8% probabilityProjected box score leadersQB passing yards: Justin Herbert, 210 yardsReceiving yards: Ladd McConkey, 50 yardsRushing yards: Omarion Hampton, 48 yardsKansas City ChiefsFirst touchdown scorer predictionsRashee Rice: 11.5% probabilityKareem Hunt: 10.6% probabilityTravis Kelce: 6.3% probabilityAnytime touchdown predictionsRashee Rice: 45.1% probabilityKareem Hunt: 42.4% probabilityTravis Kelce: 28.0% probabilityProjected box score leadersQB passing yards: Patrick Mahomes, 244 yardsReceiving yards: Rashee Rice, 71 yardsRushing yards: Kareem Hunt, 40 yardsNFL Week 15: Chargers vs. Chiefs

Get ready for Sunday’s matchup between the Chargers and Chiefs in Week 15 of the NFL season at GEHA Field at Arrowhead Stadium, which is scheduled to start at 1 p.m. EST. We emphasize that all of the NFL predictions and NFL best bets in this preview are derived from 10,000 data-driven simulations of the Chargers vs. Chiefs matchup, and they are accurate at the time of publishing to help you make better decisions when placing bets at online sportsbooks.

Please note that when engaging in online betting, it is important to exercise responsible gambling practices and seek reputable sources for accurate and up-to-date information.

If you or a loved one has questions or needs to talk to a professional about gambling, call 1-800-GAMBLER or visit 1800gambler.net for more information.

If you purchase a product or register for an account through a link on our site, we may receive compensation. By using this site, you consent to our User Agreement and agree that your clicks, interactions, and personal information may be collected, recorded, and/or stored by us and social media and other third-party partners in accordance with our Privacy Policy.