One of the top runners in the league will be featured when Christian McCaffrey and the San Francisco 49ers (9-4) host the Tennessee Titans (2-11) on Sunday, December 14, 2025.
The Titans’ offense has been bottom-five in total offense this season, generating 246.2 total yards per game, which ranks worst in the NFL. On defense, they rank 26th with 350.9 total yards allowed per contest. The 49ers are totaling 23.6 points per game offensively this season (16th in NFL), and they are giving up 20.7 points per game (eighth) on the defensive side of the ball.
Watch San Francisco 49ers vs. Tennessee Titans on Fubo! (Regional restrictions may apply)
Titans vs 49ers: Live streaming info, TV channel & game timeGame day: Sunday, December 14, 2025Game time: 4:25 p.m. ETLocation: Santa Clara, CaliforniaStadium: Levi’s StadiumTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
Watch San Francisco 49ers vs. Tennessee Titans on Fubo! (Regional restrictions may apply)
Titans vs 49ers betting lines
NFL odds courtesy of BetMGM. Odds updated Sunday at 12:29 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: 49ers (-12.5)Moneyline: 49ers (-877), Titans (+592)Total: 44.5 points
Watch San Francisco 49ers vs. Tennessee Titans on Fubo! (Regional restrictions may apply)