Can the Tennessee Titans win two games in a row?

Yes, that is the question entering Week 15 of the NFL season.

The Titans (2-11) won on the road 31-29 a week ago in Cleveland against the Browns and rookie QB Shedeur Sanders. Next up is a trip to California to play George Kittle and the San Francisco 49ers (9-4) on Dec. 14.

This week’s matchup includes Cam Ward versus Brock Purdy. Ward has thrown for 2,468 yards with nine touchdowns and seven interceptions. Purdy has thrown for 1,147 yards with nine TDs and seven interceptions. However, he has played in just five games because of injuries.

What channel is Titans vs 49ers on today?TV channel: FOX (WZTV Ch. 17 locally in Nashville)Livestream: Fubo (free trial)

Watch Titans vs 49ers live

The Tennessee Titans and San Francisco 49ers will be broadcast on FOX in Week 15 of the 2025 NFL season. Adam Amin will handle the play-by-play duties. Drew Brees is the color analyst and Kristina Pink is the sideline reporter.

Date: Sunday, Dec. 14, 2025Start time: 3:25 p.m. CT

The Tennessee Titans travel to the San Francisco 49ers in a game that starts at 3:25 p.m. CT on Dec. 14 at Levi’s Stadium in Santa Clara, California.

INJURY UPDATE: 49ers star RB Christian McCaffrey on injury report for Titans game

Titans vs 49ers betting lines

NFL odds courtesy of BetMGM. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Spread favorite: 49ers (-12.5)Moneyline: 49ers (-810), Titans (+560)Total: 44.5 points

Nick Suss, Titans beat reporter: 49ers 30, Titans 17

Gentry Estes, columnist: 49ers 31, Titans 13

Nick Gray, trending reporter: 49ers 24, Titans 17

Tom Kreager, Tennessean sports director: 49ers 35, Titans 17

Tennessee Titans 2025 schedule

All games are listed in Eastern time.

San Francisco 49ers 2025 schedule

All games are listed in Eastern time.